Advances in systemic therapy for non-small cell lung cancer

M Miller, N Hanna - Bmj, 2021 - bmj.com
Lung cancer remains a leading cause of cancer related mortality worldwide. Despite
numerous advances in treatments over the past decade, non-small cell lung cancer …

Revisiting neoadjuvant therapy in non-small-cell lung cancer

SPL Saw, BH Ong, KLM Chua, A Takano… - The Lancet …, 2021 - thelancet.com
Despite the rapidly evolving treatment landscape in advanced non-small-cell lung cancer
(NSCLC), developments in neoadjuvant and adjuvant treatments have been nascent by …

Neoadjuvant durvalumab with or without stereotactic body radiotherapy in patients with early-stage non-small-cell lung cancer: a single-centre, randomised phase 2 …

NK Altorki, TE McGraw, AC Borczuk, A Saxena… - The Lancet …, 2021 - thelancet.com
Background Previous phase 2 trials of neoadjuvant anti-PD-1 or anti-PD-L1 monotherapy in
patients with early-stage non-small-cell lung cancer have reported major pathological …

[HTML][HTML] Neoadjuvant PD-1 inhibitor (Sintilimab) in NSCLC

S Gao, N Li, S Gao, Q Xue, J Ying, S Wang… - Journal of Thoracic …, 2020 - Elsevier
Introduction Programmed death receptor-1 (PD-1) inhibitors have shown efficacy in first-line
treatment of NSCLC; however, evidence of PD-1 inhibitor as neoadjuvant treatment is …

Neoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial

JE Chaft, F Oezkan, MG Kris, PA Bunn, II Wistuba… - Nature medicine, 2022 - nature.com
In an ongoing, open-label, single-arm phase II study (NCT02927301), 181 patients with
untreated, resectable, stage IB–IIIB non-small cell lung cancer received two doses of …

[HTML][HTML] Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data

NSCLC Meta-analysis Collaborative Group - The Lancet, 2014 - Elsevier
Background Individual participant data meta-analyses of postoperative chemotherapy have
shown improved survival for patients with non-small-cell lung cancer (NSCLC). We aimed to …

[HTML][HTML] Recurrence after surgery in patients with NSCLC

H Uramoto, F Tanaka - Translational lung cancer research, 2014 - ncbi.nlm.nih.gov
Surgery remains the only potentially curative modality for early-stage non-small cell lung
cancer (NSCLC) patients and tissue availability is made possible. However, a proportion of …

Pathological response after neoadjuvant chemotherapy in resectable non-small-cell lung cancers: proposal for the use of major pathological response as a surrogate …

MD Hellmann, JE Chaft, WN William, V Rusch… - The lancet …, 2014 - thelancet.com
Improvements in outcomes for patients with resectable lung cancers have plateaued.
Clinical trials of resectable non-small-cell lung cancers with overall survival as the primary …

[HTML][HTML] 2nd ESMO Consensus Conference in Lung Cancer: locally advanced stage III non-small-cell lung cancer

WEE Eberhardt, D De Ruysscher, W Weder… - Annals of …, 2015 - Elsevier
To complement the existing treatment guidelines for all tumour types, ESMO organises
consensus conferences to focus on specific issues in each type of tumour. The 2nd ESMO …

Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

J Vansteenkiste, D De Ruysscher… - Annals of …, 2013 - annalsofoncology.org
A high proportion of NSCLC patients present with symptoms in advanced disease stage.
The aim of lung cancer screening is to reduce lung cancer-related mortality by detecting …