GDNF family neurotrophic factor signaling: four masters, one servant?

MS Airaksinen, A Titievsky, M Saarma - Molecular and Cellular …, 1999 - Elsevier
Glial cell line-derived neurotrophic factor (GDNF), and related factors neurturin (NTN),
artemin (ART), and persephin (PSP), are members of the GDNF family of neurotrophic …

The role of growth factors in tooth development

I Thesleff, M Mikkola - International review of cytology, 2002 - Elsevier
Growth factors and other paracrine signal molecules regulate communication between cells
in all developing organs. During tooth morphogenesis, molecules in several conserved …

Dental pulp cells produce neurotrophic factors, interact with trigeminal neurons in vitro, and rescue motoneurons after spinal cord injury

IV Nosrat, J Widenfalk, L Olson, CA Nosrat - Developmental biology, 2001 - Elsevier
Interactions between ingrowing nerve fibers and their target tissues form the basis for
functional connectivity with the central nervous system. Studies of the developing dental …

Dental pulp cells provide neurotrophic support for dopaminergic neurons and differentiate into neurons in vitro; implications for tissue engineering and repair in the …

IV Nosrat, CA Smith, P Mullally, L Olson… - European Journal of …, 2004 - Wiley Online Library
Glial cell line‐derived neurotrophic factor (GDNF) mRNA is highly expressed by dental pulp
cells (DPCs) prior to the initiation of dental pulp innervation. We show that radioactively …

[PDF][PDF] Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFRα2, a functional neurturin receptor

J Rossi, K Luukko, D Poteryaev, A Laurikainen, YF Sun… - Neuron, 1999 - cell.com
Glial cell line–derived neurotrophic factor (GDNF) and a related protein, neurturin (NTN),
require a GPI-linked coreceptor, either GFRα1 or GFRα2, for signaling via the …

Molecular basis of dental sensitivity: The odontoblasts are multisensory cells and express multifunctional ion channels

A Solé-Magdalena, M Martínez-Alonso… - Annals of Anatomy …, 2018 - Elsevier
Odontoblasts are the dental pulp cells responsible for the formation of dentin. In addition,
accumulating data strongly suggest that they can also function as sensory cells that mediate …

Understanding the development of oral epithelial organs through single cell transcriptomic analysis

Q Ye, A Bhojwani, JK Hu - Development, 2022 - journals.biologists.com
During craniofacial development, the oral epithelium begins as a morphologically
homogeneous tissue that gives rise to locally complex structures, including the teeth …

[HTML][HTML] The role of GDNF family ligand signalling in the differentiation of sympathetic and dorsal root ganglion neurons

U Ernsberger - Cell and tissue research, 2008 - Springer
The diversity of neurons in sympathetic ganglia and dorsal root ganglia (DRG) provides
intriguing systems for the analysis of neuronal differentiation. Cell surface receptors for the …

[HTML][HTML] The GDNF family: a role in cancer?

GC Fielder, TWS Yang, M Razdan, Y Li, J Lu, JK Perry… - Neoplasia, 2018 - Elsevier
The glial cell line–derived neurotrophic factor (GDNF) family of ligands (GFLs) comprising of
GDNF, neurturin, artemin, and persephin plays an important role in the development and …

Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfβ1 regulate …

P Kettunen, S Løes, T Furmanek, K Fjeld… - 2005 - journals.biologists.com
During development, trigeminal nerve fibers navigate and establish their axonal projections
to the developing tooth in a highly spatiotemporally controlled manner. By analyzing …