A dose-response relationship to stressors, according to the hormesis theory, is characterized
by low-dose stimulation and high-dose inhibition. It is non-linear with a low-dose optimum …

Simple Summary Isoliquiritigenin (ISL), a natural bioactive compound with a chalcone
structure, demonstrates high antitumor efficacy. This review presents a summary of the latest …

Aims Nephrotoxicity is the hallmark of anti-neoplastic drug metabolism that causes oxidative
stress. External chemical agents and prescription drugs release copious amounts of free …

Flavonoids are considered as pleiotropic, safe, and readily obtainable molecules. A large
number of recent studies have proposed that flavonoids have potential in the treatment of …

There is no doubt that significant progress has been made in tumor therapy in the past
decades. However, the discovery of new molecules with potential antitumor properties still …

Acute kidney injury (AKI) is a dose-limiting side effect of cisplatin therapy in cancer patients.
However, effective therapies for cisplatin-induced AKI are not available. Oxidative stress …

Cisplatin is an FDA approved anti-cancer drug that is widely used for the treatment of a
variety of solid tumors. However, the severe adverse effects of cisplatin, particularly kidney …

Isoliquiritigenin (ISO) is a flavonoid extracted from the root of licorice, which serves various
biological and pharmacological functions including antiinflammatory, antioxidation, liver …

Cancers represent a significant cause of morbidity and mortality worldwide. They also
impose a large economic burden on patients, their families, and health insurance systems …

Renal ischemia-reperfusion (I/R) injury leads to irreversible brain damage with serious
consequences. Activation of oxidative stress and release of inflammatory mediators are …