The primary hurdle in the treatment of cancer is acquisition of resistance by the tumor cells
toward multiple drugs and selectively targeting the cancer stem cells. This problem was …

Bacteria are rich in a wide variety of secondary metabolites, such as pigments, alkaloids,
antibiotics, and others. These bioactive microbial products serve a great application in …

Cancer is a complex disease wherein cells begin to divide abnormally and spread into
surrounding tissues. Angiogenesis plays a crucial role in tumor progression as it is required …

Failure in ovarian cancer therapy, following cytoreduction and chemotherapy, is related to
the presence of cancer stem cells-a small subpopulation of cells resistant to chemotherapy …

The history of drug development clearly shows the scale of painstaking effort leading to a
finished product–a highly biologically active agent that would be at the same time no or little …

Aims Histone deacetylases inhibitors have shown favorable antitumor activity in clinical
investigations. In the present study, we assessed the effects of a novel hydroxamic acid …

MicroRNAs play important roles in tumorigenesis of various types of cancers. MiR-320a can
inhibits cell proliferation of some cancers, but the biologic roles of miR-320a in lung cancer …

Polyether ionophore antibiotics (ionophores) represent a large group of more than 120 lipid-
soluble compounds that are widely used in veterinary medicine because of their significant …

Salinomycin is a polyether antiprotozoal antibiotic that is widely used as an animal food
additive. Some antifungal, antiparasitic, antiviral and anti‑inflammatory activities have been …

Tumors are phenotypically heterogeneous and include a small sub-population of cancer
cells (2–5% of the tumor mass) with stem-cell like properties. The cancer stem cell …