Tumor-associated myeloid cells (TAMCs) are among the most important immune cell
populations in the tumor microenvironment, and play a significant role on the efficacy of …

The ATP-adenosine pathway has emerged as a promising target for cancer therapy, but
challenges remain in achieving effective tumor control. Early research focused on blocking …

Background Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, which
makes the prognostic prediction challenging. As part of the active cross-talk between the …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense desmoplastic
stroma that impedes drug delivery, reduces parenchymal blood flow, and suppresses the …

Purinergic signalling, consisting of extracellular purines and purinergic receptors, modulates
cell proliferation, invasion and immunological reaction during cancer progression. Here, we …

S100A9 is differentially expressed in various cell types and is associated with the
development, progression and metastasis of various cancers. However, the expression …

Macrophages constitute a major component in human hepatocellular carcinoma (HCC) and
perform various functions to facilitate disease progression. Reprogramming or reconstituting …

Extracellular adenosine triphosphate (ATP) is a danger signal released by dying and
damaged cells, and it functions as an immunostimulatory signal that promotes inflammation …

Inhibition of adenosine A2A receptor (A2AR) is a promising approach for cancer
immunotherapy currently evaluated in several clinical trials. We here report that anti …

Sorafenib, a multi-kinase inhibitor, has been approved for cancer treatment for decades,
especially hepatocellular carcinoma (HCC). Although sorafenib produced substantial …