Polygenic risk scores (PRSs) aggregate the many small effects of alleles across the human
genome to estimate the risk of a disease or disease-related trait for an individual. The …

Polygenic risk scores (PRS) estimate an individual's genetic likelihood of complex traits and
diseases by aggregating information across multiple genetic variants identified from genome …

Implementation of polygenic risk scores (PRS) may improve disease prevention and
management but poses several challenges: the construction of clinically valid assays …

We developed a smartphone application, MyGeneRank, to conduct a prospective
observational cohort study (NCT03277365) involving the automated generation …

Polygenic scores—which quantify inherited risk by integrating information from many
common sites of DNA variation—may enable a tailored approach to clinical medicine …

Polygenic risk scores (PRSs) are heralded as useful tools for risk stratification and
personalized preventive care, but they are clinically useful only if they can be translated into …

The prediction of disease risks is an essential part of personalized medicine, which includes
early disease detection, prevention, and intervention. The polygenic risk score (PRS) has …

The scope of noninvasive prenatal testing (NIPT) could expand in the future to include
detailed analysis of the fetal genome. This will allow for the testing for virtually any trait with a …

Precision public health has been defined in many ways [1]. It can be viewed as an emerging
multidisciplinary field that uses genomics, big data, and machine learning/artificial …

Amyotrophic lateral sclerosis (ALS) is caused by upper and lower motor neuron loss and
has a fairly rapid disease progression, leading to fatality in an average of 2-5 years after …