Fanconi anemia is a genetic disorder that is characterized by bone marrow failure, as well
as a predisposition to malignancies including leukemia and squamous cell carcinoma …

Immune thrombocytopenia (ITP) is the most common acquired thrombocytopenia after
chemotherapy-induced thrombocytopenia. Existing guidelines describe the management …

Approximately 5–10% of all breast cancer (BC) cases are caused by germline pathogenic
variants (GPVs) in various cancer predisposition genes (CPGs). The most common …

DNA damage response is essential to human physiology. A broad spectrum of pathologies
are displayed by individuals carrying monoallelic or biallelic loss-of-function mutations in …

Fanconi anemia (FA), a chromosomal instability syndrome, is caused by inherited
pathogenic variants in any of 22 FANC genes, which cooperate in the FA/BRCA pathway …

Mitochondrial DNA (mtDNA) instability activates cGAS-dependent innate immune signaling
by unknown mechanisms. Here, we find that Fanconi anemia suppressor genes are acting …

Abstract Described by Guido Fanconi almost 100 years ago, Fanconi anemia (FA) is a rare
genetic disease characterized by developmental abnormalities, bone marrow failure (BMF) …

Fanconi anemia (FA) is characterized by physical abnormalities, bone marrow failure, and
increased risk for malignancy. Physical abnormalities, present in approximately 75% of …

Red blood cells (RBC) are specifically differentiated to transport oxygen and carbon dioxide
in the blood and they lack most organelles, including mitochondria. The autoxidation of …

Fanconi anaemia (FA) is the most frequent inherited bone marrow failure syndrome, due to
mutations in genes encoding proteins involved in replication fork protection, DNA interstrand …