Metabolism in pulmonary hypertension
W Xu, AJ Janocha, SC Erzurum - Annual review of physiology, 2021 - annualreviews.org
Pulmonary arterial hypertension (PAH) is characterized by impaired regulation of pulmonary
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …
The role of hypoxia-inducible factors in cardiovascular diseases
B Yu, X Wang, Y Song, G Xie, S Jiao, L Shi… - Pharmacology & …, 2022 - Elsevier
Cardiovascular diseases are the leading cause of death worldwide. During the development
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …
Growth of ZIF-8 Nanoparticles In Situ on Graphene Oxide Nanosheets: A Multifunctional Nanoplatform for Combined Ion-Interference and Photothermal Therapy
The regulation of intracellular ions' overload to interrupt normal bioprocesses and cause cell
death has been developed as an efficient strategy (named as ion-interference therapy/IIT) to …
death has been developed as an efficient strategy (named as ion-interference therapy/IIT) to …
Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension
Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary
hypertension (PH). However, the mechanisms by which biophysical properties of the …
hypertension (PH). However, the mechanisms by which biophysical properties of the …
Identification of microRNA-124 as a major regulator of enhanced endothelial cell glycolysis in pulmonary arterial hypertension via PTBP1 (polypyrimidine tract binding …
P Caruso, BJ Dunmore, K Schlosser, S Schoors… - Circulation, 2017 - Am Heart Assoc
Background: Pulmonary arterial hypertension (PAH) is characterized by abnormal growth
and enhanced glycolysis of pulmonary artery endothelial cells. However, the mechanisms …
and enhanced glycolysis of pulmonary artery endothelial cells. However, the mechanisms …
Metabolic and proliferative state of vascular adventitial fibroblasts in pulmonary hypertension is regulated through a microRNA-124/PTBP1 (polypyrimidine tract …
H Zhang, D Wang, M Li, L Plecitá-Hlavatá… - Circulation, 2017 - Am Heart Assoc
Background: An emerging metabolic theory of pulmonary hypertension (PH) suggests that
cellular and mitochondrial metabolic dysfunction underlies the pathology of this disease. We …
cellular and mitochondrial metabolic dysfunction underlies the pathology of this disease. We …
The metabolic basis of pulmonary arterial hypertension
G Sutendra, ED Michelakis - Cell metabolism, 2014 - cell.com
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease of the lungs
resulting in heart failure and premature death. Although, until recently, it was thought that …
resulting in heart failure and premature death. Although, until recently, it was thought that …
Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains
MK Culley, SY Chan - The Journal of clinical investigation, 2018 - Am Soc Clin Investig
Pulmonary hypertension (PH) is a heterogeneous and fatal disease of the lung vasculature,
where metabolic and mitochondrial dysfunction may drive pathogenesis. Similar to the …
where metabolic and mitochondrial dysfunction may drive pathogenesis. Similar to the …
Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and …
Mitochondria are central to cellular metabolism. The metabolic pathways of mitochondria
include fatty acid oxidation, glucose oxidation, and glutaminolysis. The initial step in glucose …
include fatty acid oxidation, glucose oxidation, and glutaminolysis. The initial step in glucose …
Increased pericyte coverage mediated by endothelial-derived fibroblast growth factor-2 and interleukin-6 is a source of smooth muscle–like cells in pulmonary …
Background—Pericytes and their crosstalk with endothelial cells are critical for the
development of a functional microvasculature and vascular remodeling. It is also known that …
development of a functional microvasculature and vascular remodeling. It is also known that …