Pulmonary arterial hypertension (PAH) is characterized by impaired regulation of pulmonary
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …

Cardiovascular diseases are the leading cause of death worldwide. During the development
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …

The regulation of intracellular ions' overload to interrupt normal bioprocesses and cause cell
death has been developed as an efficient strategy (named as ion-interference therapy/IIT) to …

Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary
hypertension (PH). However, the mechanisms by which biophysical properties of the …

Background: Pulmonary arterial hypertension (PAH) is characterized by abnormal growth
and enhanced glycolysis of pulmonary artery endothelial cells. However, the mechanisms …

Background: An emerging metabolic theory of pulmonary hypertension (PH) suggests that
cellular and mitochondrial metabolic dysfunction underlies the pathology of this disease. We …

Pulmonary arterial hypertension (PAH) is a vascular remodeling disease of the lungs
resulting in heart failure and premature death. Although, until recently, it was thought that …

Pulmonary hypertension (PH) is a heterogeneous and fatal disease of the lung vasculature,
where metabolic and mitochondrial dysfunction may drive pathogenesis. Similar to the …

Mitochondria are central to cellular metabolism. The metabolic pathways of mitochondria
include fatty acid oxidation, glucose oxidation, and glutaminolysis. The initial step in glucose …

Background—Pericytes and their crosstalk with endothelial cells are critical for the
development of a functional microvasculature and vascular remodeling. It is also known that …