Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …

Insulin synthesis in pancreatic β‐cells is initiated as preproinsulin. Prevailing glucose
concentrations, which oscillate pre‐and postprandially, exert major dynamic variation in …

Abstract Intracellular calcium (Ca 2+) is a critical coordinator of various aspects of cellular
physiology. It is increasingly apparent that changes in cellular Ca 2+ dynamics contribute to …

A number of chronic metabolic pathologies, including obesity, diabetes, cardiovascular
disease, asthma, and cancer, cluster together to present the greatest threat to human health …

Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-
mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to …

Background Wolfram syndrome (WS), a rare genetic disorder, is considered the best
prototype of endoplasmic reticulum (ER) diseases. Classical WS features are childhood …

Wolfram syndrome is a rare genetic disorder characterized by juvenile-onset diabetes
mellitus, diabetes insipidus, optic nerve atrophy, hearing loss, and neurodegeneration …

Alterations in endoplasmic reticulum (ER) calcium (Ca 2+) levels diminish insulin secretion
and reduce β-cell survival in both major forms of diabetes. The mechanisms responsible for …

The endoplasmic reticulum (ER) mediates the first steps of protein assembly within the
secretory pathway and is the site where protein folding and quality control are initiated. The …

FK506 binding (FKBP) proteins are part of the highly conserved immunophilin family and its
members have fundamental roles in the regulation of signalling pathways involved in …