Tumour heterogeneity and a long-standing paucity of effective therapies other than
chemotherapy have contributed to triple-negative breast cancer (TNBC) being the subtype …

As the field of translational 'omics has progressed, refined classifiers at both genomic and
proteomic levels have emerged to decipher the heterogeneity of breast cancer in a clinically …

Sex hormones are key determinants of gender-related differences and regulate growth and
development during puberty. They also exert a broad range modulation of immune cell …

Simple Summary The CREB-binding protein (CBP) and p300 are paralogous lysine
acetyltransferases that serve as critical co-activators for transcription factors involved in …

Breast cancer (BC) is one of the most widely diagnosed cancers and a leading cause of
cancer death among women worldwide. Globally, BC is the second most frequent cancer …

Biomarkers can be used for diagnosis, prognosis, and prediction in targeted therapy. The
estrogen receptor α (ERα) and human epidermal growth factor receptor 2 (HER2) are …

Background Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-
inducible transcription factors that govern various essential metabolic activities in the liver …

Rheumatoid arthritis (RA) is the most common inflammatory rheumatic disease and has a
female predominance of around 3: 1. The relationship between sex hormones and RA has …

Triple-negative breast cancer (TNBC) is a disease with often an aggressive course and a
poor prognosis compared to other subtypes of breast cancer. TNBC accounts for …

Desmoplastic small round cell tumor (DSRCT) is an aggressive, usually incurable sarcoma
subtype that predominantly occurs in post-pubertal young males. Recent evidence suggests …