Genome-scale CRISPR-Cas9 screening in stem cells: theories, applications and challenges

H Zhou, P Ye, W Xiong, X Duan, S Jing, Y He… - Stem Cell Research & …, 2024 - Springer
Due to the rapid development of stem cell technology, there have been tremendous
advances in molecular biological and pathological research, cell therapy as well as …

[HTML][HTML] Allogeneic hematopoietic stem cell transplantation for chronic myelomonocytic leukemia: clinical and molecular genetic prognostic factors in a Nordic …

E Wedge, JW Hansen, I Dybedal, M Creignou… - … and cellular therapy, 2021 - Elsevier
Chronic myelomonocytic leukemia (CMML) is an aggressive disease in which survival after
allogeneic hematopoietic stem cell transplantation (HCT) remains relatively poor. An …

Impact of cytoreduction and remission status on hematopoietic cell transplantation outcomes in pediatric myelodysplastic syndrome and related disorders

F Wachter, K Hebert, Y Pikman, J Yang… - Pediatric Blood & …, 2023 - Wiley Online Library
Background The role of cytoreduction prior to hematopoietic cell transplant (HCT) for
patients with pediatric myelodysplastic syndrome (MDS) and related disorders remains …

The evolution of minimal residual disease: key insights based on a bibliometric visualization analysis from 2002 to 2022

Z Yu, L Xie, J Zhang, H Lin, T Niu - Frontiers in Oncology, 2023 - frontiersin.org
Background The topic of minimal residual disease (MRD) has emerged as a crucial subject
matter in the domain of oncology in recent years. The detection and monitoring of MRD have …

Measurable (Minimal) Residual Disease in Myelodysplastic Neoplasms (MDS): Current State and Perspectives

L Zhang, G Deeb, KK Deeb, C Vale, D Peker Barclift… - Cancers, 2024 - mdpi.com
Simple Summary Myelodysplastic Neoplasms (MDS) are a type of blood cancer presenting
as ineffective production of blood cells, even though the bone marrow appears active …

The identity card of T cells—clinical utility of T-cell receptor repertoire analysis in transplantation

N Babel, U Stervbo, P Reinke, HD Volk - Transplantation, 2019 - journals.lww.com
There is a clear medical need to change the current strategy of “one-size-fits-all”
immunosuppression for controlling transplant rejection to precision medicine and targeted …

Differential effects of donor lymphocyte infusion upon treatment response and GVHD according to relapse level and donor sources in patients with myelodysplastic …

S Park, TY Kim, JH Lee, JY Lee… - Therapeutic …, 2021 - journals.sagepub.com
Introduction: Donor lymphocyte infusion (DLI) is one of the effective options for post-
transplant disease control of myelodysplastic syndrome (MDS). Its success or failure …

Strategies for minimal residual disease detection: current perspectives

G Andreani, D Cilloni - Blood and Lymphatic Cancer: Targets and …, 2019 - Taylor & Francis
Currently, the post-remission treatment in acute leukemia is based on the genetic profile of
leukemic cells at diagnosis (ie, FLT3 ITD positivity) and on the level of measurable residual …

Getting personal with myelodysplastic syndromes: is now the right time?

N Chokr, AB Pine, JP Bewersdorf… - Expert review of …, 2019 - Taylor & Francis
Introduction: Commonly used scoring systems rely on blood counts, histological and
cytological examination of bone marrow and peripheral blood as well as cytogenetic …

Next-generation sequencing for measurable residual Disease Assessment in Acute Leukemia

AE Kovach, G Raca… - Advances in …, 2021 - advancesinmolecularpathology.com
Minimal residual disease, or measurable residual disease (MRD), has emerged as one of
the most important independent prognostic factors in acute leukemia. Extrapolating from …