The approach to paediatric drug dosing needs to be based on the physiological
characteristics of the child and the pharmacokinetic parameters of the drug. This review …

Background Peppermint oil has been used for centuries as a treatment for gastrointestinal
ailments. It has been shown to have several effects on gastrointestinal physiology relevant to …

Abstract Background Growth faltering in West African children has previously been
associated with dietary exposure to aflatoxins, particularly upon weaning. However, in …

The cytochrome P450s are responsible for about 75% of phase I dependent drug
metabolism and for the metabolism of a huge amount of dietary constituents and …

The total number of paediatric formulations available only account for a small proportion of
the full therapeutic plethora required to effectively treat paediatrics and, therefore, the …

Patients with type 2 diabetes mellitus often require multifactorial pharmacological treatment
due to different comorbidities. An increasing number of concomitantly taken medications …

Many studies have attempted to explain the interindividual variability observed in drug
metabolism by assessing the impact of SNPs in genes implicated in drug absorption …

The human cytochrome P4503A forms show expression patterns subject to developmental
influence. CYP3A7 and CYP3A4 are generally classified as the major fetal and adult liver …

CYP3A4 is the most abundant isoform of cytochrome P450 (CYP) in adult human liver. It
metabolizes numerous clinically, physiologically, and toxicologically important compounds …

Pairs of forward and reverse primers and TaqMan probes specific to each human
cytochrome P450 isoform were prepared. Analysis of the mRNA level of each CYP isoform …