Background HDAC6, a structurally and functionally distinct member of the HDAC family, is
an integral part of multiple cellular functions such as cell proliferation, apoptosis …

Highlights•Fatty acids target the cancer epigenome.•Fatty acids are histone deacetylase
inhibitors.•Fatty acids exert anti-cancer effects.Histone acetylation is a key epigenetic event …

A growing body of evidence supports that pentadecanoic acid (C15: 0), an odd-chain
saturated fat found in butter, is an essential fatty acid that is necessary in the diet to support …

Pentadecanoic acid (C15: 0) is an essential odd-chain saturated fatty acid with broad
activities relevant to protecting cardiometabolic, immune, and liver health. C15: 0 activates …

Background Non-small cell lung cancer (NSCLC) accounts for almost 85% of lung cancer-
related deaths worldwide. Xihuang Pill (XHP) is a representative anticancer Chinese …

As an emerging dietary essential fatty acid, pentadecanoic acid (C15: 0) is expected to have
bioactive metabolites with broad health benefits. Here, we evaluated …

Odd-chain saturated fatty acids generally serve as specific biomarkers of dietary
components and dairy intake, some of which have anticancer properties. This study was …

Histone deacetylation is a key biochemical event associated with transcriptional regulation.
Histone deacetylases (HDACs) mediate the deacetylation of histones. Fatty acids have been …

Objectives: The molecular landscape of non-muscle-invasive (NMIBC) and muscle-invasive
(MIBC) bladder cancer based on molecular characteristics is essential but poorly …

Gemcitabine, as a first-line antitumor drug, has attracted extensive attention. However the
occurrence of drug resistance limits its clinical utilization. In this paper, a gemcitabine …