Quercetin has been confirmed to possess antihistamine, anti-inflammatory, antiviral,
immunomodulatory, and antioxidant properties. Herein, we evaluated their antitumor activity …

Recently, noscapine was reported as anticancer drug. Unlike, colchicine and
podophyllotoxin, noscapine did not depolymerize microtubules even at stoichiometric …

We have previously shown that a non-toxic noscapinoid, EM011 binds tubulin without
altering its monomer/polymer ratio. EM011 is more active than the parent molecule …

Microtubules, composed of α/β tubulin heterodimers, represent a validated target for cancer
chemotherapy. Thus, tubulin-and microtubule-binding antimitotic drugs such as taxanes and …

Breast cancer (BC) is the most common female cancer in terms of incidence and mortality
worldwide. Tamoxifen (Nolvadex) is a widely prescribed, oral anti-estrogen drug for the …

The scaffold structure of noscapine (an antitussive plant alkaloid) was modified by inducting
N‐aryl methyl pharmacophore at C‐9 position of the isoquinoline ring to rationally design …

Noscapine, the tubulin-binding anticancer agent, when administered orally, requires high
ED 50 (300–600 mg/kg), whereas intravenous administration (10 mg/kg) results in rapid …

Molecular mechanism (s) responsible for drug resistance of non-small cell lung cancer
(NSCLC) cells to cisplatin was investigated. Results showed that cisplatin (50μM)-induced …

BZL101 is an aqueous extract from the Scutellaria barbata plant shown to have anticancer
properties in a variety of human cancers. In order to determine its efficacy on human …

Noscapine, recently identified as anticancer due to its microtubule-modulating properties. It
is presently in Phase I/II clinical trials. The therapeutic efficacy of noscapine has been …