Poor water solubility of many drugs has emerged as one of the major challenges in the
pharmaceutical world. Polymer-based amorphous solid dispersions have been considered …

Objectives: This study investigated the impact of polymer excipients on a typical cocrystal for
sacubitril (SAC) and valsartan (VAL), aiming to guide optional formulation design and …

The high-throughput drying and encapsulation technique called electrospraying assisted by
pressurized gas (EAPG) was used for the first time to produce nanostructured valsartan …

Modifying pharmaceutical forms already available on the market is a strategy used by the
pharmaceutical industries for optimizing the performance of different drugs. In the present …

The central purpose of this study was to evaluate the impact of drug particle size and
crystalline state on valsartan (VAL) formulations in order to improve its dissolution and …

Coamorphous formation in binary systems of valsartan (Val) with 4, 4′-bipyridine (Bipy)
and trimethoprim (Tri) was investigated for mixtures with a mole fraction of 0.16~ 0.86 of …

This study aimed to improve dissolution rate of valsartan in an acidic environment and
consequently its oral bioavailability by solid dispersion formulation. Valsartan was selected …

Valsartan (VAL) is an antihypertensive drug marketed in an amorphous form. Amorphous
materials can have different physicochemical properties depending on preparation method …

Objective (s): Chronic hypertension is a pervasive morbidity and the leading risk factor for
cardiovascular diseases. Valsartan, as an antihypertensive drug, has low solubility and …

Novel thiazolidine-2, 4-dione (TZD) based pyrimidine derivatives have been synthesized by
Knoevenagel condensation reaction between thiazolidine-2, 4-dione and amino pyrimidinyl …