Novel approaches to target fibroblast mechanotransduction in fibroproliferative diseases

M Ezzo, B Hinz - Pharmacology & therapeutics, 2023 - Elsevier
The ability of cells to sense and respond to changes in mechanical environment is vital in
conditions of organ injury when the architecture of normal tissues is disturbed or lost. Among …

Role of TRPV4 on vascular tone regulation in pathophysiological states

T Matsumoto, K Taguchi, T Kobayashi - European Journal of Pharmacology, 2023 - Elsevier
Vascular tone regulation is a key event in controlling blood flow in the body. Endothelial
cells (ECs) and vascular smooth muscle cells (VSMCs) help regulate the vascular tone …

[HTML][HTML] Role of TRP Channels in Metabolism-Related Diseases

F Wu, S Bu, H Wang - International Journal of Molecular Sciences, 2024 - mdpi.com
Metabolic syndrome (MetS), with its high prevalence and significant impact on
cardiovascular disease, poses a substantial threat to human health. The early identification …

[HTML][HTML] TRPV4 Activation during Guinea Pig Airway Smooth Muscle Contraction Promotes Ca2+ and Na+ Influx

LM Montaño, A Carbajal-García… - Pharmaceuticals, 2024 - mdpi.com
Airway smooth muscle (ASM) contraction is determined by the increase in intracellular Ca2+
concentration ([Ca2+] i) caused by its release from the sarcoplasmic reticulum (SR) or by …

[HTML][HTML] The Yin and Yang of Breast Cancer: Ion Channels as Determinants of Left–Right Functional Differences

S Masuelli, S Real, P McMillen, M Oudin… - International Journal of …, 2023 - mdpi.com
Breast cancer is a complex and heterogeneous disease that displays diverse molecular
subtypes and clinical outcomes. Although it is known that the location of tumors can affect …