The locus coeruleus (LC) is the noradrenaline (norepinephrine, NE)-containing nucleus in
the brainstem and innervates into widespread brain regions. This LC-NE system plays a …

Background The earliest brain pathology related to Alzheimer's disease (AD) is
hyperphosphorylated soluble tau in the noradrenergic locus coeruleus (LC) neurons. Braak …

Here an overview is provided on therapeutic/neuroprotective effects of Lithium (Li+) in
neurodegenerative and psychiatric disorders focusing on the conspicuous action of Li+ …

The prevalence of depression has dramatically increased, and it has been estimated that
over 300 million people suffer from depression all over the world. Depression is highly …

The noradrenergic locus coeruleus (LC) is among the first regions of the brain affected by
pathology in both Alzheimer's disease (AD) and Parkinson's disease (PD), but the reasons …

Locus Coeruleus (LC) is the main noradrenergic nucleus of the brain, which is involved in
many physiological functions including cognition; its impairment may be crucial in the …

Alzheimer's disease (AD) poses a significant global health concern over the next several
decades. Multiple hypotheses have been put forth that attempt to explain the underlying …

Alzheimer's Disease (AD) represents the main degenerative dementia. Its neuropathological
hallmarks are β-amyloid plaques (APs) and neurofibrillary tangles (NFT), which lead to …

Aging is a complex process that produces profound effects on the brain. Although a number
of external factors can promote the initiation and progression of brain aging, peripheral and …

Chronic stress has been shown to promote numerous aging-related diseases, and to
accelerate the aging process itself. Of particular interest is the impact of stress on …