Further incorporation of genomic and molecular data in pediatric AML will allow for
additional refinements in risk stratification to enable the tailoring of treatment intensity. These …

Pediatric acute myeloid leukemia is a rare and heterogeneous disease in relation to
morphology, immunophenotyping, germline and somatic cytogenetic and genetic …

Abstract Purpose of Review Acute myeloid leukemia (AML) in children remains a
challenging disease to cure with suboptimal outcomes particularly when compared to the …

New methods like panel-based RNA fusion sequencing (RNA-FS) promise improved
diagnostics in various malignancies. We here analyzed the impact of RNA-FS on the initial …

Acute myeloid leukaemia (AML), typically a disease of elderly adults, affects 8 children per
million each year, with the highest paediatric incidence in infants aged 0–2 of 18 per million …

Introduction: Trisomy 8 is one of the most common cytogenetic alterations in acute myeloid
leukemia (AML), with a frequency between 10% and 15%. Areas covered: The authors …

Acute myeloid leukemia (AML) with the t (7; 12)(q36; p13) translocation occurs only in very
young children and has a poor clinical outcome. The expected oncofusion between …

Acute myeloid leukemia (AML) is a clinically, morphologically, and genetically
heterogeneous disorder. Like many malignancies, the genomic landscape of pediatric AML …

Acute myeloid leukaemia carrying the translocation t (7; 12)(q36; p13) is an adverse-risk
leukaemia uniquely observed in infants. Despite constituting up to 30% of cases in under 2 …

Acute myeloid leukemia (AML) results from aberrant hematopoietic processes and these
changes are frequently initiated by chromosomal translocations. One particular subtype …