Ion channels in cancer: are cancer hallmarks oncochannelopathies?
N Prevarskaya, R Skryma, Y Shuba - Physiological reviews, 2018 - journals.physiology.org
Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …
all cancer cell genotypes generally translate into several common pathophysiological …
Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy: thematic review series: biology of lipid rafts
F Mollinedo, C Gajate - Journal of lipid research, 2020 - ASBMB
Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts,
play a critical role in the compartmentalization of signaling pathways. Physical segregation …
play a critical role in the compartmentalization of signaling pathways. Physical segregation …
Transient receptor potential canonical (TRPC) channels: then and now
Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …
TRPC1, Orai1, and STIM1 in SOCE: Friends in tight spaces
IS Ambudkar, LB de Souza, HL Ong - Cell calcium, 2017 - Elsevier
Store-operated calcium entry (SOCE) is a ubiquitous Ca 2+ entry pathway that is activated in
response to depletion of ER-Ca 2+ stores and critically controls the regulation of …
response to depletion of ER-Ca 2+ stores and critically controls the regulation of …
The multifaceted role of TMEM16A in cancer
D Crottès, LY Jan - Cell Calcium, 2019 - Elsevier
The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over
decades, TMEM16A over-expression and contribution to prognosis have been widely …
decades, TMEM16A over-expression and contribution to prognosis have been widely …
Calcium permeable channels in cancer hallmarks
S Tajada, C Villalobos - Frontiers in pharmacology, 2020 - frontiersin.org
Cancer, the second cause of death worldwide, is characterized by several common criteria,
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …
TRPC6 channels are required for proliferation, migration and invasion of breast cancer cell lines by modulation of Orai1 and Orai3 surface exposure
I Jardin, R Diez-Bello, JJ Lopez, PC Redondo… - Cancers, 2018 - mdpi.com
Transient receptor potential channels convey signaling information from a number of stimuli
to a wide variety of cellular functions, mainly by inducing changes in cytosolic Ca2+ …
to a wide variety of cellular functions, mainly by inducing changes in cytosolic Ca2+ …
TRPC Channels in the SOCE Scenario
Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels
that contribute to the modulation of a number of physiological functions in a variety of cell …
that contribute to the modulation of a number of physiological functions in a variety of cell …
The role of TRPC1 in modulating cancer progression
Calcium ions (Ca2+) play an important role as second messengers in regulating a plethora
of physiological and pathological processes, including the progression of cancer. Several …
of physiological and pathological processes, including the progression of cancer. Several …
TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy
A Marcotti, J Fernández-Trillo, A González… - Brain, 2023 - academic.oup.com
Chemotherapy-induced peripheral neuropathy is a frequent, disabling side effect of
anticancer drugs. Oxaliplatin, a platinum compound used in the treatment of advanced …
anticancer drugs. Oxaliplatin, a platinum compound used in the treatment of advanced …