Background: Current guidelines for the treatment of chronic obstructive pulmonary disease
(COPD) recommend the use of long-acting bronchodilators in the maintenance …

Systemic exposure to anticholinergics used for chronic obstructive pulmonary disease
(COPD) may lead to side effects. This study assessed safety, tolerability, and …

Tiotropium is a potent, long-acting, selective anticholinergic bronchodilator. Treatment with
tiotropium produces sustained improvements in lung function, particularly FEV1 (peak …

Background: The proven efficacy of several anti-cholinergics and β2-agonists and their
combinations in both chronic obstructive pulmonary disease (COPD) and asthma strongly …

Objective and background: The addition of an alternative class of long‐acting bronchodilator
is recommended for COPD patients who do not respond satisfactorily to monotherapy. The …

We explored the additive effect of titrated oral theophylline in patients with stable chronic
obstructive pulmonary disease (COPD) who received both tiotropium, 18μg od, and …

Because additive effects of inhaled corticosteroids and long-acting anticholinergics are
unclear, we undertook this study to compare the efficacy of tiotropium alone and tiotropium …

Résumé Introduction Les recommandations sur la prise en charge de la
bronchopneumopathie chronique obstructive (BPCO) dépendent de sa sévérité et s' …

Premature discontinuation from clinical trials may bias results against effective therapies. In
the present study mortality rates were retrospectively reviewed in a 6-month, randomised …

Anticholinergics and β-agonists reduce bronchoconstriction through different mechanisms,
and there is a long history of combination therapy with short-acting agents in these classes …