Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

MD Roberts, JJ McCarthy… - Physiological …, 2023 - journals.physiology.org
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Recommendation on design, execution, and reporting of animal atherosclerosis studies: a scientific statement from the American Heart Association

A Daugherty, AR Tall, MJAP Daemen… - … , and vascular biology, 2017 - Am Heart Assoc
Animal studies are a foundation for defining mechanisms of atherosclerosis and potential
targets of drugs to prevent lesion development or reverse the disease. In the current …

[图书][B] Critical aspects of EPA's IRIS assessment of inorganic arsenic: interim report

National Research Council, Division on Earth… - 2013 - books.google.com
The US Environmental Protection Agency (EPA) Integrated Risk Information System (IRIS)
program develops toxicologic assessments of environmental contaminants. IRIS …

Genetic effects on the commensal microbiota in inflammatory bowel disease patients

H Aschard, V Laville, ET Tchetgen, D Knights… - PLoS …, 2019 - journals.plos.org
Several bacteria in the gut microbiota have been shown to be associated with inflammatory
bowel disease (IBD), and dozens of IBD genetic variants have been identified in genome …

Congruence of additive and non-additive effects on gene expression estimated from pedigree and SNP data

JE Powell, AK Henders, AF McRae, J Kim… - PLoS …, 2013 - journals.plos.org
There is increasing evidence that heritable variation in gene expression underlies genetic
variation in susceptibility to disease. Therefore, a comprehensive understanding of the …

The evolution and adaptive potential of transcriptional variation in sticklebacks—signatures of selection and widespread heritability

EH Leder, RJS McCairns, T Leinonen… - Molecular biology …, 2015 - academic.oup.com
Evidence implicating differential gene expression as a significant driver of evolutionary
novelty continues to accumulate, but our understanding of the underlying sources of …

Evaluation and comparison of different breast cancer prognosis scores based on gene expression data

A Chowdhury, PD Pharoah, OM Rueda - Breast Cancer Research, 2023 - Springer
Background Breast cancer is one of the three most common cancers worldwide and is the
most common malignancy in women. Treatment approaches for breast cancer are diverse …

Comprehensive multiple eQTL detection and its application to GWAS interpretation

B Zeng, LR Lloyd-Jones, GW Montgomery… - Genetics, 2019 - academic.oup.com
Expression QTL (eQTL) detection has emerged as an important tool for unraveling the
relationship between genetic risk factors and disease or clinical phenotypes. Most studies …

Gene expression profiles associated with acute myocardial infarction and risk of cardiovascular death

J Kim, N Ghasemzadeh, DJ Eapen, NC Chung… - Genome medicine, 2014 - Springer
Background Genetic risk scores have been developed for coronary artery disease and
atherosclerosis, but are not predictive of adverse cardiovascular events. We asked whether …

Blood-informative transcripts define nine common axes of peripheral blood gene expression

M Preininger, D Arafat, J Kim, AP Nath… - PLoS …, 2013 - journals.plos.org
We describe a novel approach to capturing the covariance structure of peripheral blood
gene expression that relies on the identification of highly conserved Axes of variation …