Oxidative stress (OS) is primarily caused by the formation of free radicals and reactive
oxygen species; it is considered as one of the prominent factors in slowing down and …

Cholesterol is a crucial component of membrane bilayers by regulating their structural and
functional properties. Cholesterol traffics to different cellular compartments including …

Objective Lipotoxic hepatocyte injury is a primary event in non-alcoholic steatohepatitis
(NASH), but the mechanisms of lipotoxicity are not fully defined. Sphingolipids and free …

The mycotoxin ochratoxin A (OTA) is a widespread contaminant in human and animal food
products. Previous studies in rats revealed that melatonin (Mel) exhibits a preventive effect …

Diabetes mellitus is one of the most common metabolic diseases in the developed world,
and is associated either with the impaired secretion of insulin or with the resistance of cells …

During autophagy, cytosolic cargo is sequestered into double-membrane vesicles called
autophagosomes. The contributions of specific lipids, such as cholesterol, to the membranes …

Niemann–Pick type C disease (NPCD) was first described in 1914 and affects approximately
1 in 150 000 live births. It is characterized clinically by diverse symptoms affecting liver …

Under aerobic conditions, mitochondrial oxidative phosphorylation (OXPHOS) converts the
energy released by nutrient oxidation into ATP, the currency of living organisms. The whole …

Emerging data suggest an association between obesity and infectious diseases. Although
the mechanisms underlying this link are not well established, a number of potential factors …

Alcoholic (ASH) and nonalcoholic steatohepatitis (NASH) are advanced stages of fatty liver
disease and two of the most prevalent forms of chronic liver disease. ASH and NASH are …