Inflammatory gastrointestinal (GI) diseases and malignancies are associated with growing
morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain …

Aberrant activation of Notch signaling plays an oncogenic role in cancer development.
Jagged1 (JAG1) is an important Notch ligand that triggers Notch signaling through cell-cell …

Osteosarcoma is the most common primary malignant bone tumor and has a high fatality
rate in children and adolescents. Recently, an increasing amount of evidence has …

The Notch family consists of four highly conserved transmembrane receptors. The release of
the active intracellular domain requires the enzymatic activity of γ-secretase. Notch is …

Gastric carcinoma (GC) is the second leading cause of cancer-related mortality worldwide.
The efficacy of standard chemotherapy for GC, such as cisplatin (CDDP), is dissatisfactory …

Traditional anticancer therapies are often unable to completely eradicate the tumor bulk due
to multi-drug resistance (MDR) of cancers. A number of mechanisms such as micro …

MicroRNAs (miRNAs) are noncoding single‐stranded RNAs, approximately 20‐24
nucleotides in length, known as powerful posttranscriptional regulators. miRNAs play …

The long non‑coding RNA nuclear enriched abundant transcript 1 (NEAT1) has important
roles in the regulation of multiple cell functions, such as proliferation, apoptosis and …

Aim To understand the mechanism of long non‐coding RNA (LncRNA) HOTAIR on renal
interstitial fibrosis (RIF) by regulating Notch1 pathway via the modulation of miR‐124 …

Central nervous system injuries and diseases, such as ischemic stroke, spinal cord injury,
neurodegenerative diseases, glioblastoma, multiple sclerosis, and the resulting …