[HTML][HTML] Genetic predictors of human chronic pain conditions
K Zorina-Lichtenwalter, CB Meloto, S Khoury… - Neuroscience, 2016 - Elsevier
Chronic pain conditions are multifactorial disorders with a high frequency in the population.
Their pathophysiology is often unclear, and treatment is inefficient. During the last 20 years …
Their pathophysiology is often unclear, and treatment is inefficient. During the last 20 years …
Dual therapy with anti‐CGRP monoclonal antibodies and botulinum toxin for migraine prevention: is there a rationale?
Objective To narratively review the pathophysiological rationale of dual therapy with anti‐
calcitonin gene‐related peptide monoclonal antibodies and botulinum toxin type A in …
calcitonin gene‐related peptide monoclonal antibodies and botulinum toxin type A in …
[PDF][PDF] Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine
Sensitization of trigeminal ganglion neurons contributes to primary headache disorders such
as migraine, but the specific neuronal and non-neuronal trigeminal subtypes that are …
as migraine, but the specific neuronal and non-neuronal trigeminal subtypes that are …
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
Calcitonin gene-related peptide (CGRP) is a widely expressed neuropeptide that has a
major role in sensory neurotransmission. The CGRP receptor is a heterodimer of the …
major role in sensory neurotransmission. The CGRP receptor is a heterodimer of the …
Fremanezumab—a humanized monoclonal anti-CGRP antibody—inhibits thinly myelinated (Aδ) but not unmyelinated (C) meningeal nociceptors
Calcitonin gene-related peptide (CGRP), the most abundant neuropeptide in primary
afferent sensory neurons, is strongly implicated in the pathophysiology of migraine …
afferent sensory neurons, is strongly implicated in the pathophysiology of migraine …
Selective inhibition of trigeminovascular neurons by fremanezumab: a humanized monoclonal anti-CGRP antibody
A large body of evidence supports an important role for calcitonin gene-related peptide
(CGRP) in migraine pathophysiology. This evidence gave rise to a global effort to develop a …
(CGRP) in migraine pathophysiology. This evidence gave rise to a global effort to develop a …
[HTML][HTML] The molecular fingerprint of dorsal root and trigeminal ganglion neurons
The dorsal root ganglia (DRG) and trigeminal ganglia (TG) are clusters of cell bodies of
highly specialized sensory neurons which are responsible for relaying information about our …
highly specialized sensory neurons which are responsible for relaying information about our …
CGRP and its receptors
The calcitonin gene‐related peptide (CGRP) neuropeptide system is an important but still
evolving target for migraine. A fundamental consideration for all of the current drugs in …
evolving target for migraine. A fundamental consideration for all of the current drugs in …
Sex‐related influences in migraine
Migraine is a common neurological disorder with significantly higher incidence and
prevalence in women than men. The presentation of the disease in women is modulated by …
prevalence in women than men. The presentation of the disease in women is modulated by …
The migraine premonitory phase
N Karsan, P Bose, PJ Goadsby - CONTINUUM: Lifelong Learning …, 2018 - journals.lww.com
PURPOSE OF REVIEW The premonitory phase of migraine is defined as the presence of
nonpainful symptomatology occurring hours to days before the onset of headache …
nonpainful symptomatology occurring hours to days before the onset of headache …