[HTML][HTML] Preterm brain injury, antenatal triggers, and therapeutics: timing is key

DRMG Ophelders, R Gussenhoven, L Klein… - Cells, 2020 - mdpi.com
With a worldwide incidence of 15 million cases, preterm birth is a major contributor to
neonatal mortality and morbidity, and concomitant social and economic burden Preterm …

Therapeutic hypothermia for mild neonatal encephalopathy: a systematic review and meta-analysis

U Kariholu, P Montaldo, T Markati, PJ Lally… - Archives of Disease in …, 2020 - fn.bmj.com
Objectives To examine if therapeutic hypothermia reduces the composite outcome of death,
moderate or severe disability at 18 months or more after mild neonatal encephalopathy …

The neuroprotective mechanisms of naringenin: Inhibition of apoptosis through the PI3K/AKT pathway after hypoxic-ischemic brain damage

L Li, Z Lin, J Yuan, P Li, Q Wang, N Cho… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Naringenin (NGN) is a widely distributed flavonoid with
potent antioxidant and neuroprotective properties. Neuroprotective agents play a crucial role …

Quercetin alleviates neonatal hypoxic-ischemic brain injury by inhibiting microglia-derived oxidative stress and TLR4-mediated inflammation

K Le, Z Song, J Deng, X Peng, J Zhang, L Wang… - Inflammation …, 2020 - Springer
Objective and design Microglia stimulated by oxygen glucose deprivation (OGD) were
treated with quercetin to investigate the effect on oxidative stress and the inflammatory …

Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study

L Shipley, C Gale, D Sharkey - Archives of Disease in Childhood-Fetal …, 2021 - fn.bmj.com
Objective Hypoxic-ischaemic encephalopathy (HIE) remains a leading cause of neonatal
mortality and neurodisability. We aimed to determine the incidence of HIE and management …

[HTML][HTML] Networks of cortical activity show graded responses to perinatal asphyxia

T Syvälahti, A Tuiskula, P Nevalainen… - Pediatric …, 2023 - nature.com
Background Perinatal asphyxia often leads to hypoxic-ischemic encephalopathy (HIE) with a
high risk of neurodevelopmental consequences. While moderate and severe HIE link to high …

[HTML][HTML] Extracellular vesicle-microRNAs as diagnostic biomarkers in preterm neonates

EA Schiller, K Cohen, X Lin, R El-Khawam… - International Journal of …, 2023 - mdpi.com
Neonates born prematurely (< 37 weeks of gestation) are at a significantly increased risk of
developing inflammatory conditions associated with high mortality rates, including …

Hypoxic-ischemic encephalopathy and mitochondrial dysfunction: facts, unknowns, and challenges

M Rodríguez, V Valez, C Cimarra… - Antioxidants & redox …, 2020 - liebertpub.com
Significance: Hypoxic-ischemic events due to intrapartum complications represent the
second cause of neonatal mortality and initiate an acute brain disorder known as hypoxic …

Association of acute respiratory failure in early childhood with long-term neurocognitive outcomes

RS Watson, SR Beers, LA Asaro, C Burns, MJ Koh… - Jama, 2022 - jamanetwork.com
Importance Approximately 23 700 US children undergo invasive mechanical ventilation for
acute respiratory failure annually, with unknown long-term effects on neurocognitive …

The association of placental pathology and neurodevelopmental outcomes in patients with neonatal encephalopathy

AC Stone, KC Strickland, DT Tanaka, JB Gilner… - Pediatric …, 2023 - nature.com
Background Studies conflict on how acute versus chronic placental pathology impacts
outcomes after neonatal encephalopathy from presumed hypoxic-ischemic encephalopathy …