Effect of lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal vs standard care ventilation on 90-day mortality in patients with acute …

JJ McNamee, MA Gillies, NA Barrett, GD Perkins… - Jama, 2021 - jamanetwork.com
Importance In patients who require mechanical ventilation for acute hypoxemic respiratory
failure, further reduction in tidal volumes, compared with conventional low tidal volume …

Inhaled nitric oxide in acute respiratory distress syndrome subsets: rationale and clinical applications

S Redaelli, M Pozzi, M Giani, A Magliocca… - Journal of Aerosol …, 2023 - liebertpub.com
Acute respiratory distress syndrome (ARDS) is a life-threatening condition, characterized by
diffuse inflammatory lung injury. Since the coronavirus disease 2019 (COVID-19) pandemic …

[HTML][HTML] Inhaled nitric oxide: role in the pathophysiology of cardio-cerebrovascular and respiratory diseases

D Signori, A Magliocca, K Hayashida, JA Graw… - Intensive Care Medicine …, 2022 - Springer
Nitric oxide (NO) is a key molecule in the biology of human life. NO is involved in the
physiology of organ viability and in the pathophysiology of organ dysfunction, respectively …

[HTML][HTML] Presence of comorbidities alters management and worsens outcome of patients with acute respiratory distress syndrome: insights from the LUNG SAFE study

E Rezoagli, BA McNicholas, F Madotto, T Pham… - Annals of intensive …, 2022 - Springer
Background The impact of underlying comorbidities on the clinical presentation,
management and outcomes in patients with ARDS is poorly understood and deserves …

Clinical characteristics, physiological features, and outcomes associated with hypercapnia in patients with acute hypoxemic respiratory failure due to COVID–19 …

AM Tsonas, M Botta, J Horn, L Morales-Quinteros… - Journal of critical …, 2022 - Elsevier
Purpose We determined the incidence of hypercapnia and associations with outcome in
invasively ventilated COVID–19 patients. Methods Posthoc analysis of a national …

Hypocapnia is an independent predictor of in‐hospital mortality in acute heart failure

WJ Tang, BK Xie, W Liang, YZ Zhou… - ESC Heart …, 2023 - Wiley Online Library
Aims Acute heart failure (AHF) poses a major threat to hospitalized patients for its high
mortality rate and serious complications. The aim of this study is to determine whether …

[HTML][HTML] Association between the time-varying arterial carbon dioxide pressure and 28-day mortality in mechanically ventilated patients with acute respiratory distress …

R Zhang, H Chen, R Teng, Z Li, Y Yang, H Qiu… - BMC Pulmonary …, 2023 - Springer
Background Recent studies have shown an association between baseline arterial carbon
dioxide pressure (PaCO2) and outcomes in patients with acute respiratory distress …

Impact of arterial CO2 retention in patients with moderate or severe ARDS

A Maamar, F Delamaire, F Reizine… - Respiratory …, 2023 - rc.rcjournal.com
BACKGROUND: Lung-protective ventilation (reduced tidal volume and limited plateau
pressure) may lead to CO2 retention. Data about the impact of hypercapnia in patients with …

Association Between Dyscapnia, Ventilatory Variables, and Mortality in Patients With Acute Respiratory Distress Syndrome—A Retrospective Cohort Study

J Braunsteiner, L Castro, C Wiessner… - Journal of Intensive …, 2024 - journals.sagepub.com
Background: This study aimed to investigate the associations between dyscapnia,
ventilatory variables, and mortality. We hypothesized that the association between …

[HTML][HTML] The relationship between ventilatory ratio (VR) and 28-day hospital mortality by restricted cubic splines (RCS) in 14,328 mechanically ventilated ICU patients

Y Yang, Y Chi, S Yuan, Q Zhang, L Su, Y Long… - BMC Pulmonary …, 2022 - Springer
Background Previous studies found that high levels of ventilatory ratio (VR) were associated
with a poor prognosis due to worse ventilatory efficiency in acute respiratory distress …