Synthetic biology tools to engineer microbial communities for biotechnology

NS McCarty, R Ledesma-Amaro - Trends in biotechnology, 2019 - cell.com
Microbial consortia have been used in biotechnology processes, including fermentation,
waste treatment, and agriculture, for millennia. Today, synthetic biologists are increasingly …

Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications

Z Li, Y Jiang, FP Guengerich, L Ma, S Li… - Journal of Biological …, 2020 - ASBMB
Cytochrome P450 enzymes (P450s) are broadly distributed among living organisms and
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …

Terpene synthases as metabolic gatekeepers in the evolution of plant terpenoid chemical diversity

PS Karunanithi, P Zerbe - Frontiers in plant science, 2019 - frontiersin.org
Terpenoids comprise tens of thousands of small molecule natural products that are widely
distributed across all domains of life. Plants produce by far the largest array of terpenoids …

Expansion within the CYP71D subfamily drives the heterocyclization of tanshinones synthesis in Salvia miltiorrhiza

Y Ma, G Cui, T Chen, X Ma, R Wang, B Jin… - Nature …, 2021 - nature.com
Tanshinones are the bioactive nor-diterpenoid constituents of the Chinese medicinal herb
Danshen (Salvia miltiorrhiza). These groups of chemicals have the characteristic furan D …

Distributing a metabolic pathway among a microbial consortium enhances production of natural products

K Zhou, K Qiao, S Edgar, G Stephanopoulos - Nature biotechnology, 2015 - nature.com
Metabolic engineering of microorganisms such as Escherichia coli and Saccharomyces
cerevisiae to produce high-value natural metabolites is often done through functional …

[HTML][HTML] Cytochrome P450 enzymes: a driving force of plant diterpene diversity

U Bathe, A Tissier - Phytochemistry, 2019 - Elsevier
In plant terpene biosynthesis, oxidation of the hydrocarbon backbone produced by terpene
synthases is typically carried out by cytochrome P450 oxygenases (CYPs). The …

[HTML][HTML] Carnosic acid

S Birtić, P Dussort, FX Pierre, AC Bily, M Roller - Phytochemistry, 2015 - Elsevier
Carnosic acid (salvin), which possesses antioxidative and antimicrobial properties, is
increasingly exploited within the food, nutritional health and cosmetics industries. Since its …

Full‐length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues of Salvia miltiorrhiza and …

Z Xu, RJ Peters, J Weirather, H Luo, B Liao… - The Plant …, 2015 - Wiley Online Library
Summary Danshen, Salvia miltiorrhiza Bunge, is one of the most widely used herbs in
traditional Chinese medicine, wherein its rhizome/roots are particularly valued. The …

Analysis of the genome sequence of the medicinal plant Salvia miltiorrhiza

H Xu, J Song, H Luo, Y Zhang, Q Li, Y Zhu, J Xu, Y Li… - Molecular plant, 2016 - cell.com
Salvia miltiorrhiza Bunge (Danshen) is a medicinal plant of the Lamiaceae family, and its
dried roots have long been used in traditional Chinese medicine with hydrophilic phenolic …

[HTML][HTML] Tanshinone and salvianolic acid biosynthesis are regulated by SmMYB98 in Salvia miltiorrhiza hairy roots

X Hao, Z Pu, G Cao, D You, Y Zhou, C Deng… - Journal of Advanced …, 2020 - Elsevier
Salvia miltiorrhiza Bunge is an herb rich in bioactive tanshinone and salvianolic acid
compounds. It is primarily used as an effective medicine for treating cardiovascular and …