Enterohepatic recycling occurs by biliary excretion and intestinal reabsorption of a solute,
sometimes with hepatic conjugation and intestinal deconjugation. Cycling is often …

Ventricular electrical storm (VES) is a clinical scenario characterized by the clustering of
multiple episodes of sustained ventricular arrhythmias (VA) over a short duration. Patients …

We studied the time-and frequency-domain indexes of heart rate variability (HRV) in 653
patients without any evidence of heart disease relative to age, gender, heart rate, body mass …

Background Atrial fibrillation occurs frequently in patients with congestive heart failure and
commonly results in clinical deterioration and hospitalization. Sinus rhythm may be …

In severe heart failure many deaths are sudden and are presumed to be due to ventricular
arrhythmias. The GESICA trial evaluated the effect of low-dose amiodarone on two-year …

Grapefruit juice can alter oral drug pharmacokinetics by different mechanisms. Irreversible
inactivation of intestinal cytochrome P450 (CYP) 3A4 is produced by commercial grapefruit …

Amiodarone is an effective antiarrhythmic medication frequently used in practice for both
ventricular and atrial arrhythmias. Though classified as a class III antiarrhythmic, it affects all …

The mechanism of the anti-anginal effect of perhexiline is unclear but appears to involve a
shift in cardiac metabolism from utilization of fatty acid to that of carbohydrate. We tested the …

Background Although trials of amiodarone therapy in patients with congestive heart failure
have produced discordant results with regard to effects on survival, most studies have …

Amiodarone has emerged as the leading antiarrhythmic therapy for termination and
prevention of ventricular arrhythmia in different clinical settings because of its proven …