Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions
AEG Osman, MW Deininger - Blood reviews, 2021 - Elsevier
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by a reciprocal
translocation [t (9; 22)(q34; q11. 2)] that leads to the fusion of ABL1 gene sequences (9q34) …
translocation [t (9; 22)(q34; q11. 2)] that leads to the fusion of ABL1 gene sequences (9q34) …
[HTML][HTML] Gene quantification using real-time quantitative PCR: an emerging technology hits the mainstream
DG Ginzinger - Experimental hematology, 2002 - Elsevier
The recent flood of reports using real-time Q-PCR testifies to the transformation of this
technology from an experimental tool into the scientific mainstream. Many of the applications …
technology from an experimental tool into the scientific mainstream. Many of the applications …
Real-time reverse transcription PCR (qRT-PCR) and its potential use in clinical diagnosis
SA Bustin, R Mueller - Clinical Science, 2005 - portlandpress.com
qRT-PCR (real-time reverse transcription-PCR) has become the benchmark for the detection
and quantification of RNA targets and is being utilized increasingly in novel clinical …
and quantification of RNA targets and is being utilized increasingly in novel clinical …
Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects
VHJ Van der Velden, A Hochhaus, G Cazzaniga… - Leukemia, 2003 - nature.com
Detection of minimal residual disease (MRD) has prognostic value in many hematologic
malignancies, including acute lymphoblastic leukemia, acute myeloid leukemia, chronic …
malignancies, including acute lymphoblastic leukemia, acute myeloid leukemia, chronic …
Chronic myeloid leukaemia as a model of disease evolution in human cancer
JV Melo, DJ Barnes - Nature Reviews Cancer, 2007 - nature.com
Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that
evolve through a multi-step process. CML is also one of the best examples of a disease that …
evolve through a multi-step process. CML is also one of the best examples of a disease that …
Real‐time polymerase chain reaction
J Wilhelm, A Pingoud - Chembiochem, 2003 - Wiley Online Library
Real‐time PCR is the state‐of‐the‐art technique to quantify nucleic acids for mutation
detection, genotyping and chimerism analysis. Since its development in the 1990s, many …
detection, genotyping and chimerism analysis. Since its development in the 1990s, many …
The biology of CML blast crisis
B Calabretta, D Perrotti - Blood, 2004 - ashpublications.org
Chronic myelogenous leukemia (CML) evolves from a chronic phase characterized by the
Philadelphia chromosome as the sole genetic abnormality into blast crisis, which is often …
Philadelphia chromosome as the sole genetic abnormality into blast crisis, which is often …
[HTML][HTML] The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein
The oncogenic BCR/ABL kinase activity induces and maintains chronic myelogenous
leukemia (CML). We show here that, in BCR/ABL-transformed cells and CML blast crisis …
leukemia (CML). We show here that, in BCR/ABL-transformed cells and CML blast crisis …
[HTML][HTML] Mechanisms of disease progression and resistance to tyrosine kinase inhibitor therapy in chronic myeloid leukemia: an update
Chronic myeloid leukemia (CML) is characterized by the presence of the BCR-ABL1 fusion
gene, which encodes a constitutive active tyrosine kinase considered to be the pathogenic …
gene, which encodes a constitutive active tyrosine kinase considered to be the pathogenic …
BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2
The arrest of differentiation is a feature of both chronic myelogenous leukemia cells in
myeloid blast crisis and myeloid precursors that ectopically express the p210BCR-ABL …
myeloid blast crisis and myeloid precursors that ectopically express the p210BCR-ABL …