The dissolution mechanism, molecular dynamics simulation and thermodynamic analysis of nirmatrelvir (treatment of COVID-19) in aqueous ethanol mixtures
X Cai, C Yang, L Chen, R Li, C Du - Journal of Molecular Liquids, 2023 - Elsevier
This research investigates the cosolvent effect of nirmatrelvir (treatment of COVID-19) in
ethanol+ water mixtures. The result shows that the maximum solubility in mole fraction is …
ethanol+ water mixtures. The result shows that the maximum solubility in mole fraction is …
Direct Oral FXa Inhibitors Binding to Human Serum Albumin: Spectroscopic, Calorimetric, and Computational Studies
N Mariño-Ocampo, DF Rodríguez… - International Journal of …, 2023 - mdpi.com
Direct FXa inhibitors are an important class of bioactive molecules (rivaroxaban, apixaban,
edoxaban, and betrixaban) applied for thromboprophylaxis in diverse cardiovascular …
edoxaban, and betrixaban) applied for thromboprophylaxis in diverse cardiovascular …
Equilibrium solubility, solvent effect, and equation correlations of cyclosporine in twenty mono solvents and four binary mixtures
In this study, the solid–liquid equilibrium solubility of cyclosporine in 20 pure solvents and
four binary mixtures at 298.15 K were determined using shake-flask technique. Solid-state …
four binary mixtures at 298.15 K were determined using shake-flask technique. Solid-state …
Synergistic solvation effect and modeling of itraconazole solubility in eight binary mixtures (dichloromethane and chloroform+ primary alcohol) at the range of 288.15 K …
In this study, the solubility and apparent thermodynamic parameters of itraconazole in
chlorinated methane (dichloromethane and chloroform)+ primary alcohol (methanol …
chlorinated methane (dichloromethane and chloroform)+ primary alcohol (methanol …
Solubility measurement, correlation, and dissolution thermodynamics of 2, 4, 6, 8, 10, 12-hexanitrohexaazaisowurtzitane· 1, 3, 5, 7-tetranitro-1, 3, 5, 7-tetrazocane …
Q Jia, Y Liu, R Chen, J Wang, Y Song, S Zhang… - Journal of Molecular …, 2023 - Elsevier
The solubility of 2HNIW· HMX co-crystal in two binary solvent mixtures (ethanol+ methyl
acetate, and 1, 2-dichloroethane+ methyl acetate) was measured by gravimetric method at …
acetate, and 1, 2-dichloroethane+ methyl acetate) was measured by gravimetric method at …
Effects of intermolecular interactions and solvent properties on the solid-liquid phase equilibrium of isosorbide 5-mononitrate
Y Cao, J Zhang, X Wan, S Jia, G Zhang, Z Zhou… - Journal of Molecular …, 2022 - Elsevier
Abstract Isosorbide 5-mononitrate (5-SIMN) is an organic nitrate pharmaceutical for the
treatment of angina pectoris. In this work, first, the solubility of 5-ISMN in ten organic solvents …
treatment of angina pectoris. In this work, first, the solubility of 5-ISMN in ten organic solvents …
Dissolution behavior, thermodynamic analysis and molecular simulation of lithium bis (fluorosulfonyl) imide in organic solvent at 273.15 K to 313.15 K
X Fang, B Mei, X Yang, Y Yu, C Cao, L Xu… - The Journal of Chemical …, 2024 - Elsevier
The solubility of LiFSI in ethanol, n-propanol, isopropanol, n-butanol, methyl acetate, ethyl
acetate, propyl acetate, butyl acetate, dimethyl carbonate, ethyl methyl carbonate, diethyl …
acetate, propyl acetate, butyl acetate, dimethyl carbonate, ethyl methyl carbonate, diethyl …
Synergistic Solvation as the Enhancement of Local Mixing
S Shimizu, N Matubayasi - The Journal of Physical Chemistry B, 2024 - ACS Publications
Mixing two solvents can sometimes make a much better solvent than expected from their
weighted mean. This phenomenon, called synergistic solvation, has commonly been …
weighted mean. This phenomenon, called synergistic solvation, has commonly been …
Research on dissolution behavior of N-hydroxyphthalimide in three binary solvents: Measurement, modeling, molecular simulation and thermodynamics
Y Wan, H He, F Li, X Gao, Y Li - Journal of Molecular Liquids, 2022 - Elsevier
Solubility data, relevant thermodynamic parameters as well as molecular interactions of N-
hydroxyphthalimide (NHPI) in three binary solvents of (2-methoxyethanol (EGME), N, N …
hydroxyphthalimide (NHPI) in three binary solvents of (2-methoxyethanol (EGME), N, N …
The development of an innovative method to improve the dissolution performance of rivaroxaban
Recent advancements in the formulation of solid dosage forms involving active ingredient-
cyclodextrin complexes have garnered considerable attention in pharmaceutical research …
cyclodextrin complexes have garnered considerable attention in pharmaceutical research …