Endocrine toxicity of cancer immunotherapy targeting immune checkpoints
Immune checkpoints are small molecules expressed by immune cells that play critical roles
in maintaining immune homeostasis. Targeting the immune checkpoints cytotoxic T …
in maintaining immune homeostasis. Targeting the immune checkpoints cytotoxic T …
CTLA-4 in regulatory T cells for cancer immunotherapy
Simple Summary In the fight against cancer, immunotherapies have given great hope after
encouraging results in clinical investigations showing complete remission in some patients …
encouraging results in clinical investigations showing complete remission in some patients …
Tumor immunology and tumor evolution: intertwined histories
J Galon, D Bruni - Immunity, 2020 - cell.com
Cancer is a complex disease whose outcome depends largely on the cross-talk between the
tumor and its microenvironment. Here, we review the evolution of the field of tumor …
tumor and its microenvironment. Here, we review the evolution of the field of tumor …
In Situ Separable Nanovaccines with Stealthy Bioadhesive Capability for Durable Cancer Immunotherapy
L Yu, M Yu, W Chen, S Sun, W Huang… - Journal of the …, 2023 - ACS Publications
Because of tumor heterogeneity and the immunosuppressive tumor microenvironment, most
cancer vaccines typically do not elicit robust antitumor immunological responses in clinical …
cancer vaccines typically do not elicit robust antitumor immunological responses in clinical …
Molecular and biochemical aspects of the PD-1 checkpoint pathway
VA Boussiotis - New England Journal of Medicine, 2016 - Mass Medical Soc
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Collateral damage: insulin-dependent diabetes induced with checkpoint inhibitors
AM Stamatouli, Z Quandt, AL Perdigoto, PL Clark… - Diabetes, 2018 - Am Diabetes Assoc
Insulin-dependent diabetes may occur in patients with cancers who are treated with
checkpoint inhibitors (CPIs). We reviewed cases occurring over a 6-year period at two …
checkpoint inhibitors (CPIs). We reviewed cases occurring over a 6-year period at two …
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy
With recent approvals for multiple therapeutic antibodies that block cytotoxic T lymphocyte
associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) in melanoma …
associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) in melanoma …
Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation
Co-inhibitory receptors, such as CTLA-4 and PD-1, have an important role in regulating T
cell responses and have proven to be effective targets in the setting of chronic diseases …
cell responses and have proven to be effective targets in the setting of chronic diseases …
Targets of immune escape mechanisms in cancer: basis for development and evolution of cancer immune checkpoint inhibitors
Simple Summary The tumor immune escape mechanisms are key factors in cancer
progression and metastasis. They are an undeniable hurdle for successful cancer treatment …
progression and metastasis. They are an undeniable hurdle for successful cancer treatment …
Incidence of endocrine dysfunction following the use of different immune checkpoint inhibitor regimens: a systematic review and meta-analysis
R Barroso-Sousa, WT Barry, AC Garrido-Castro… - JAMA …, 2018 - jamanetwork.com
Importance If not promptly recognized, endocrine dysfunction can be life threatening. The
incidence and risk of developing such adverse events (AEs) following the use of immune …
incidence and risk of developing such adverse events (AEs) following the use of immune …