The following summarises the contents of both this review and its predecessor in this journal
(Iisalo, 1977). The two reviews should be read in conjunction with each other. Digoxin is …

This review deals briefly with the clinical pharmacology of digoxin and reviews in some
depth the problems inherent in methods of digoxin measurement. Digoxin-like factors …

The foregoing discussion leads to several general conclusions regarding the use of digoxin
in the pediatric patient. First, pharmacokinetic studies indicate that somewhat higher doses …

Although the pharmacologic effects of cardiac glycosides are well known today, their
mechanism of action is still subject to speculation. It is, however, generally accepted that …

Serum, right atrial myocardium and skeletal muscle collected from 32 adult patients
undergoing open heart surgery were analyzed for digoxin by radioimmunoassay …

A standard format for a Clinical Pharmacokinetic Summary is proposed. It consists of a
heading, table, notes, and references for each drug reviewed. The table presents a unified …

• To establish whether there is a difference between infants and adults in the relationship of
serum levels of digoxin to dosage or the ratio of myocardial to serum digoxin levels, the …

The metabolism of digoxin is fairly extensive in the majority of patients receiving this drug,
and the metabolites possess varying degrees of cardioactivity. Immunoassays measure the …

Pediatric Clinical Pharmacology of Digoxin Page 1 Symposium on Progress in Drug Therapy
for Children Pediatric Clinical Pharmacology of Digoxin Lester F. Soyka, MD* The purpose of …

Recent research suggests that the cardiotoxic as well as the neurotoxic effects of digitalis
may be mediated by the central nervous system. Therefore brain regions implicated in the …