T follicular helper (Tfh) cells provide essential help to B cells for effective antibody-mediated
immune responses. Although the crucial function of these CD4+ T cells in infection and …

Immunotherapy has greatly improved cancer outcomes, yet variability in response and off-
target tissue damage can occur with these treatments, including immune checkpoint …

The programmed cell death protein 1 (PD‐1) signaling pathway is a major source of
dampened T cell activity in the tumor microenvironment. While clinical approaches to …

Immune checkpoint inhibitors (ICIs) are potentially life‐saving cancer therapies that can
trigger immune‐related adverse events (irAEs). irAEs can impact any organ and range in …

Checkpoint inhibitors have been used with chemotherapy to improve antitumor efficacy.
However, overcoming the immunosuppressive effect of chemotherapeutics remains a …

Abstract SHP-1 (Src homology region 2 domain-containing phosphatase 1) is a well-known
negative regulator of T cells, whereas its close homolog SHP-2 is the long-recognized main …

Monoclonal antibodies targeting the programmed cell death protein 1 (PD-1) remain the
most prevalent cancer immunotherapy both as a monotherapy and in combination with …

Anti-neutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis (AAV) is a
necrotizing vasculitis mainly involving small blood vessels. It is demonstrated that T cells are …

Conclusion: Our findings elucidate the potential mechanism of anti-PD-1–mediated
intratumoral Tregs accumulation in HCC and uncover the tissue adaptation characteristics of …

Acute respiratory distress syndrome (ARDS) is a severe lung condition with a high mortality
rate and a lack of effective drug therapy. In this work, we developed mesenchymal stem cell …