[HTML][HTML] Myocarditis and inflammatory cardiomyopathy: current evidence and future directions

C Tschöpe, E Ammirati, B Bozkurt… - Nature Reviews …, 2021 - nature.com
Inflammatory cardiomyopathy, characterized by inflammatory cell infiltration into the
myocardium and a high risk of deteriorating cardiac function, has a heterogeneous …

Myocardial ischaemia–reperfusion injury and cardioprotection in perspective

G Heusch - Nature Reviews Cardiology, 2020 - nature.com
Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …

Role of cardiac macrophages on cardiac inflammation, fibrosis and tissue repair

WP Lafuse, DJ Wozniak, MVS Rajaram - Cells, 2020 - mdpi.com
The immune system plays a pivotal role in the initiation, development and resolution of
inflammation following insult or damage to organs. The heart is a vital organ which supplies …

Obesity, hypertension, and cardiac dysfunction: novel roles of immunometabolism in macrophage activation and inflammation

AJ Mouton, X Li, ME Hall, JE Hall - Circulation research, 2020 - Am Heart Assoc
Obesity and hypertension, which often coexist, are major risk factors for heart failure and are
characterized by chronic, low-grade inflammation, which promotes adverse cardiac …

Immune cells and immunotherapy for cardiac injury and repair

JG Rurik, H Aghajanian, JA Epstein - Circulation research, 2021 - Am Heart Assoc
Cardiac injury remains a major cause of morbidity and mortality worldwide. Despite
significant advances, a full understanding of why the heart fails to fully recover function after …

Role of inflammatory chemokines in hypertension

TP Mikolajczyk, P Szczepaniak, F Vidler… - Pharmacology & …, 2021 - Elsevier
Hypertension is associated with immune cells activation and their migration into the kidney,
vasculature, heart and brain. These inflammatory mechanisms are critical for blood pressure …

Targeted immunomodulation therapy for cardiac repair by platelet membrane engineering extracellular vesicles via hitching peripheral monocytes

Q Li, Z Huang, Q Wang, J Gao, J Chen, H Tan, S Li… - Biomaterials, 2022 - Elsevier
Immune regulation therapies have been considered promising in the treatment of
myocardial ischemia reperfusion (MI/R) injury. Mesenchymal stem cells derived extracellular …

Role of neutrophils in cardiac injury and repair following myocardial infarction

Y Ma - Cells, 2021 - mdpi.com
Neutrophils are first-line responders of the innate immune system. Following myocardial
infarction (MI), neutrophils are quickly recruited to the ischemic region, where they initiate …

Multifunctional elastomer cardiac patches for preventing left ventricle remodeling after myocardial infarction in vivo

Y Yao, A Li, S Wang, Y Lu, J Xie, H Zhang, D Zhang… - Biomaterials, 2022 - Elsevier
Myocardial infarction (MI) is still a major cause of mortality and morbidity worldwide.
Elastomer cardiac patches have shown great potential in preventing left ventricle (LV) …

Atorvastatin-pretreated mesenchymal stem cell-derived extracellular vesicles promote cardiac repair after myocardial infarction via shifting macrophage polarization …

Y Ning, P Huang, G Chen, Y Xiong, Z Gong, C Wu, J Xu… - BMC medicine, 2023 - Springer
Abstract Background Extracellular vesicles (EVs) derived from bone marrow mesenchymal
stem cells (MSCs) pretreated with atorvastatin (ATV)(MSCATV-EV) have a superior cardiac …