Vascular smooth muscle cells (VSMCs) are the predominant cell type in the medial layer of
the aorta, which plays a critical role in the maintenance of aortic wall integrity. VSMCs have …

To determine the roles of endoplasmic reticulum (ER) stress and trained immunity, we
performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from …

Spiral artery remodeling is the process by which the uterine vessels become large bore low
resistance conduits, allowing delivery of high volumes of maternal blood to the placenta to …

Neutrophil extracellular traps (NETs), composed of DNA, histones, and antimicrobial
proteins, are released by neutrophils in response to pathogens but are also recognized for …

Increasing evidence shows that epigenetics also plays a key role in regulating the
pathogenetic mechanism of all types of aortic aneurysms. It is well-known that epigenetic …

Diabetes is a group of medical conditions characterized by the body's inability to effectively
control blood glucose levels, due to either insufficient insulin synthesis in type 1 diabetes or …

Background: Molecular markers and pathways involved in the etiology and pathophysiology
of bicuspid aortopathy are poorly understood. The aim here is to delve into the molecular …

Background: Marfan Syndrome (MFS) is a monogenic multisystem disorder resulting from
mutations in fibrillin-1, resulting in thoracic aortic aneurysm. Currently, effective treatments …