Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential
step for the expression of most eukaryotic genes. Alternative splicing enables the regulated …

Abstract Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling is one of the most important intracellular pathways, which can be considered as a …

Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …

Disparities in cancer care have been a long-standing challenge. We estimated the genetic
ancestry of The Cancer Genome Atlas patients, and performed a pan-cancer analysis on the …

Kinases are attractive anticancer targets due to their central role in the growth, survival, and
therapy resistance of tumor cells. This review explores the two primary kinase classes, the …

More than 95% of the 20,000 to 25,000 transcribed human genes undergo alternative RNA
splicing, which increases the diversity of the proteome. Isoforms derived from the same gene …

Abstract Purpose African Americans experience greater prostate cancer risk and mortality
than do Caucasians. An analysis of pooled phase III data suggested differences in overall …

Men of predominantly African Ancestry (AA) have higher prostate cancer (CaP) incidence
and worse survival than men of predominantly European Ancestry (EA). While …

The largest US cancer health disparity exists in prostate cancer, with Black men having more
than a two-fold increased risk of dying from prostate cancer compared to all other races. This …