Combination of Genomic Landsscape and 3D Culture Functional Assays Bridges Sarcoma Phenotype to Target and Immunotherapy

F de Nigris, C Meo, W Palinski - Cells, 2023 - mdpi.com
Genomic-based precision medicine has not only improved tumour therapy but has also
shown its weaknesses. Genomic profiling and mutation analysis have identified alterations …

Targeted therapies for the treatment of soft tissue sarcoma

JW Fuchs, BC Schulte, JR Fuchs, M Agulnik - Frontiers in Oncology, 2023 - frontiersin.org
Soft tissue sarcomas are rare malignant tumors derived from mesenchymal cells that have a
high morbidity and mortality related to frequent occurrence of advanced and metastatic …

Alleviative effect of lactoferrin interventions against the hepatotoxicity induced by titanium dioxide nanoparticles

W Zhang, J Sun, F Liu, S Li, X Wang, L Su… - Biological Trace Element …, 2024 - Springer
The current study was designed to investigate the alleviative effect of lactoferrin
interventions against the hepatotoxicity induced by titanium dioxide nanoparticles (TiO2 …

Improving anti-tumor efficacy of low-dose Vincristine in rhabdomyosarcoma via the combination therapy with FOXM1 inhibitor RCM1

J Donovan, Z Deng, F Bian, S Shukla… - Frontiers in …, 2023 - frontiersin.org
Rhabdomyosarcoma (RMS) is a highly metastatic soft-tissue sarcoma that often develops
resistance to current therapies, including vincristine. Since the existing treatments have not …

Zebrafish Insights into Nanomaterial Toxicity: A Focused Exploration on Metallic, Metal Oxide, Semiconductor, and Mixed-Metal Nanoparticles

C Mutalik, Nivedita, C Sneka, DI Krisnawati… - International journal of …, 2024 - mdpi.com
Nanomaterials are widely used in various fields, and ongoing research is focused on
developing safe and sustainable nanomaterials. Using zebrafish as a model organism for …

Evaluation of cardiotoxicity of anthracycline‐containing chemotherapy regimens in patients with bone and soft tissue sarcomas: A study of the FDA adverse event …

Z Mo, Y Deng, Y Bao, J Liu, Y Jiang - Cancer Medicine, 2023 - Wiley Online Library
Objectives To assess the occurrence of cardiotoxicity in patients with tumors receiving
anthracycline‐based chemotherapy, especially for sarcomas. Methods This study …

Transforming Growth Factor Beta and Alveolar Rhabdomyosarcoma: A Challenge of Tumor Differentiation and Chemotherapy Response

B Bhushan, R Iranpour, A Eshtiaghi… - International Journal of …, 2024 - mdpi.com
Alveolar rhabdomyosarcoma (ARMS), an invasive subtype of rhabdomyosarcoma (RMS), is
associated with chromosomal translocation events resulting in one of two oncogenic fusion …

Five-Fraction Proton Therapy for the Treatment of Skull Base Chordomas and Chondrosarcomas: Early Results of a Prospective Series and Description of a Clinical …

M Sallabanda, JA Vera, JM Pérez, R Matute… - Cancers, 2023 - mdpi.com
Simple Summary Chordomas and chondrosarcomas are rare and invasive tumors that
frequently arise in the skull base. The extremely high local recurrence rate, due to the …

Co-Delivery of an Innovative Organoselenium Compound and Paclitaxel by pH-Responsive PCL Nanoparticles to Synergistically Overcome Multidrug Resistance in …

D Mathes, LB Macedo, TB Pieta, BC Maia… - Pharmaceutics, 2024 - mdpi.com
In this study, we designed the association of the organoselenium compound 5′-Seleno-
(phenyl)-3′-(ferulic-amido)-thymidine (AFAT-Se), a promising innovative nucleoside …

[PDF][PDF] Advanced breast cancer metastasized in the brain: treatment standards and innovations

E Klaas, E Sung, E Azizi, M Martinez… - J Cancer Metastasis …, 2023 - academia.edu
Breast cancer continues to be a difficult disease to treat due to high rates of metastasis.
Metastasis to the brain presents a unique and often overlooked challenge. In this focused …