Endolysosomal proteases such as cysteinyl and aspartyl cathepsins play diverse roles in
inflammatory autoimmune diseases, cancers, and neurodegenerative diseases. Cysteinyl …

A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was
held in Palermo, Italy on 7-8 April 2009. Three lectures from that Symposium by G. Campisi …

Butyrylcholinesterase (BChE) has been more and more attractive for treating
neurodegenerative diseases, especially Alzheimer's disease (AD). In this study, we …

purpose. To study the neuroprotective effects of intravitreal fluocinolone acetonide (FA) in
Royal College of Surgeons (RCS) rats. methods. Five-week-old RCS rats were divided into …

Background Numerous epidemiological studies demonstrate that genetic background
modifies the onset and the progression of Alzheimer's disease and related …

α-1-antichymotrypsin (ACT), is an acute phase protein and a protease inhibitor produced by
the liver and brain. ACT is involved in the pathogenesis of Alzheimer's disease (AD), since …

Neurodegenerative processes associated with Alzheimer's disease (AD) are accompanied
by reactive astrogliosis and microglia activation and a role for chronic inflammation in the …

Data mining of a large data base from the population longitudinal study named “The
Conselice Study” has been the focus of the present investigation. Initially, 65 years old or …

Gene variants that promote inflammation and cholesterol metabolism have been associated
with acute myocardial infarction (AMI) and Alzheimer's disease (AD). We investigated a …

Background Alzheimer's disease (AD) is one of the most frequent cause of
neurodegenerative disorder in the elderly. Inflammation has been implicated in brain …