Simple Summary Human primary liver cancers have a poor prognosis. At present, there are
limited treatment alternatives, and to understand the molecular aspects of liver …

A lack of relevant genetic models and cell lines hampers our understanding of
hepatoblastoma pathogenesis and the development of new therapies for this neoplasm …

Hepatoblastoma (HB) and pediatric hepatocellular carcinoma (HCC) are rare primary
malignant liver cancers in children and young adults. HB is the most common and accounts …

Pediatric hepatoblastoma is the most common primary liver cancer in infants and children.
Studies of hepatoblastoma that focus exclusively on tumor cells demonstrate sparse somatic …

Background & Aims Hepatoblastoma (HB) is the most frequent childhood liver cancer.
Patients with aggressive tumors have limited therapeutic options; therefore, a better …

Pediatric liver tumors are very rare tumors with the most common diagnosis being
hepatoblastoma. While hepatoblastomas are predominantly sporadic, around 15% of cases …

Liver cancer is characterized by aggressive growth and high mortality. Asialoglycoprotein
receptor 1 (ASGR1), which is expressed almost exclusively in liver cells, is reduced in liver …

Background In response to hypoxia, tumor cells undergo transcriptional reprogramming
including upregulation of carbonic anhydrase (CA) IX, a metalloenzyme that maintains acid …

Conclusions: Our findings illustrate the cellular architecture and developmental trajectories
of HB via integrative bulk and single‐cell transcriptome analyses, thus establishing a …

A TGF-β–dominant chemoresistant phenotype of hepatoblastoma... : Hepatology A TGF-β–dominant
chemoresistant phenotype of hepatoblastoma associated with aflatoxin exposure in children …