Aberrant activation of signal transduction pathways can transform a normal cell to a
malignant one and can impart survival properties that render cancer cells resistant to …

The progression of cancers and neurodegenerative disorders is largely defined by a set of
molecular determinants that are either complementarily deregulated, or share remarkably …

Background Lung cancer is the leading cause of cancer-related death worldwide. Surgical
resection remains the definitive curative treatment for early-stage disease offering an overall …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID), autism and
schizophrenia, have high socioeconomic impact, yet poorly understood etiologies. A recent …

Large-scale cancer sequencing studies of patient cohorts have statistically implicated many
genes driving cancer growth and progression, and their identification has yielded substantial …

Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …

Over the last decade, the use of targeted therapies has immensely increased in the
treatment of cancer. However, treatment for endometrial carcinomas (ECs) has lagged …

Purpose Neurodevelopmental disorders (NDD) caused by protein phosphatase 2A (PP2A)
dysfunction have mainly been associated with de novo variants in PPP2R5D and PPP2CA …

Somatic mutation of the protein phosphatase 2A (PP2A) Aα-subunit gene PPP2R1A is
highly prevalent in high-grade endometrial carcinoma. The structural, molecular, and …

Type II endometrial carcinomas (ECs) are responsible for most endometrial cancer-related
deaths due to their aggressive nature, late stage detection and high tolerance for standard …