Background Evidence suggests that amyloid β (Aβ) peptides play an important role in the
degeneration of neurons during the development of Alzheimer's disease (AD), the prevalent …

Deposition of β-amyloid protein in the brain is a neuropathological hallmark of Alzheimer's
disease. An additional feature of this disease is an upregulation of the lysosomal system …

The injection of amyloid β-peptide (Aβ) into rat CNS has been reported to induce cellular
neuropathology. The present study investigated whether multiple intrahippocampal …

Clinical trials for Alzheimer's disease (AD) modification have recently started to target the
earlier prodromal and pre-symptomatic stages in the belief that disease modification efforts …

The deposition of 4-kDa amyloid β peptide in the brain is a prominent feature of several
human diseases. Such process is heterogeneous in terms of causative factors, biochemical …

The possibility that brain aging in rats exhibits regional variations of the type found in
humans was studied using lysosomal chemistry as a marker. Age-related (two vs 12months; …

The insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor participates in
the trafficking of lysosomal enzymes from the trans-Golgi network or the cell surface to …

Alteration in the lysosomal system (LS) may represent a central mechanism in
neurodegeneration. 6-Hydroxydopamine (6-OHDA) induces oxidative stress and cell death …

The present invention provides a model for studying the development of, and/or pathologies
associated with neurodegenerative diseases, and agents that can alter such development …

Aspartyl protease Cathepsin D (CTSD) has been suggested to play a role in the
pathogenesis of sporadic Alzheimer's disease (AD) due to interference with protein …