Inflammation is an important driver of atherosclerosis, the underlying pathology of
cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is …

Diabetes mellitus type II and obesity are two important causes of death in modern society.
They are characterized by low-grade chronic inflammation and metabolic dysfunction (meta …

Tissue injury triggers a complex series of cellular responses, starting from inflammation
activated by tissue and cell damage and proceeding to healing. By clearing cell debris …

The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory
disease and cancer. Here, we assess the response of immune cells to lactate in the context …

Macrophages act as scavengers, modulating the immune response against pathogens and
maintaining tissue homeostasis. Metabolism governs macrophage differentiation …

Neutrophils are cells at the frontline of innate immunity that can quickly activate effector
functions to eliminate pathogens upon stimulation. However, little is known about the …

The gut microbiota is implicated in immune system functions. Regulation of the metabolic
processes occurring in immune cells is crucial for the maintenance of homeostasis and …

Cellular lipid metabolism and homeostasis are controlled by sterol regulatory-element
binding proteins (SREBPs). In addition to performing canonical functions in the …