Epidemiological sex differences in anxiety disorders and major depression are well
characterized. Yet the circuits and mechanisms that contribute to these differences are …

Research into cognitive functions across psychological disorders suggests that cognitive
deficiencies may be present across multiple disorders, potentially pointing to a …

Background Childhood maltreatment is the most important preventable cause of
psychopathology accounting for about 45% of the population attributable risk for childhood …

A growing body of research has examined the impact of childhood adversity on neural
structure and function. Advances in our understanding of the neurodevelopmental …

Objective: Determine whether a novel psychosocial treatment for positive affect improves
clinical status and reward sensitivity more than a form of cognitive behavioral therapy that …

Depression is associated with alterations in corticostriatal reward circuitry. One
pathophysiological pathway that may drive these changes is inflammation. Biomarkers of …

Background Childhood maltreatment is a potent predictor of poor mental health across the
life span. We argue that there is a need to improve the understanding of the mechanisms …

Anhedonia, or loss of interest or pleasure in usual activities, is characteristic of depression,
some types of anxiety, as well as substance abuse and schizophrenia. Anhedonia is a …

Abstract The National Institute of Mental Health (NIMH)'fast-fail'approach seeks to improve
too-often-misleading early-phase drug development methods by incorporating biomarker …

Background Two objectives of the NIMH Research Domain Criteria (RDoC) initiative are to
identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) …