Introduction Perinatal asphyxia (PA) still causes significant morbidity and mortality.
Therapeutic hypothermia (TH) is the only effective therapy for neonates with moderate to …

Children show important developmental and maturational changes, which may contribute
greatly to pharmacokinetic (PK) variability observed in pediatric patients. These PK …

Background Therapeutic hypothermia (TH) is a widely practiced neuroprotective strategy for
neonates with hypoxic-ischemic encephalopathy. Induced hypothermia is associated with …

Introduction Every year thousands of children undergo surgery for congenital heart disease.
Cardiac surgery requires the use of cardiopulmonary bypass, which can have unexpected …

Ceftazidime is an antibiotic commonly used to treat bacterial infections in term neonates
undergoing controlled therapeutic hypothermia (TH) for hypoxic-ischemic encephalopathy …

Background Allopurinol, an xanthine oxidase (XO) inhibitor, is a promising intervention that
may provide neuroprotection for neonates with hypoxic-ischemic encephalopathy (HIE) …

Many neonates undergoing whole body hypothermia (WBH) following moderate to severe
perinatal asphyxia may also suffer from renal impairment. While recent data suggest WBH …

INTRODUCTION—Perinatal asphyxia is caused by a lack of oxygen to organ systems due to
a hypoxic or ischemic insult that occurs within close temporal proximity to labor (peripartum) …

Abstract Background The CRUCIAL trial (NCT04217421) is investigating the effect of
postnatal and perioperative administration of allopurinol on postoperative brain injury in …

Aims Little is known about the population pharmacokinetics (PPK) of vancomycin in
neonates with perinatal asphyxia treated with therapeutic hypothermia (TH). We aimed to …