Emerging PEGylated non-biologic drugs

EJ Park, J Choi, KC Lee, DH Na - Expert Opinion on Emerging …, 2019 - Taylor & Francis
Introduction: PEGylation is a well-established technology for improving the therapeutic value
of drugs by attaching polyethylene glycol (PEG). The first PEGylated enzyme products …

PEGylation of therapeutic oligonucletides: From linear to highly branched PEG architectures

X Lu, K Zhang - Nano research, 2018 - Springer
PEGylation, the attachment of poly (ethylene glycol)(PEG), has been adopted to improve the
pharmacokinetic properties of oligonucleotide therapeutics for nearly 30 years. Prior efforts …

[HTML][HTML] From synthesis to characterization of site-selective PEGylated proteins

LH Belén, CO Rangel-Yagui… - Frontiers in …, 2019 - frontiersin.org
Covalent attachment of therapeutic proteins to polyethylene glycol (PEG) is widely used for
the improvement of its pharmacokinetic and pharmacological properties, as well as the …

Drug and protein delivery by polymer conjugation

A Grigoletto, K Maso, A Mero, A Rosato… - Journal of Drug Delivery …, 2016 - Elsevier
Drug and protein delivery techniques and methods, which, in most cases, are concurrently
investigated from the very time a new molecular entity is proposed, have become valuable …

Enzymatic approaches to new protein conjugates

A Grigoletto, K Maso, G Pasut - Polymer-protein conjugates, 2020 - Elsevier
Until recently, polymer–protein PEGylation has for the most part been characterized by
chemical approaches to conjugation, and, in fact, the majority of conjugates approved for …

Utilization of a multiple cloning site as a versatile platform for DNA triblock copolymer synthesis

J Shin, S Li - Bioconjugate Chemistry, 2019 - ACS Publications
DNA-containing block copolymers have utility in a wide range of biomedical applications.
However, synthesis of these hybrid materials, especially ones with complex chain structures …