Emerging PEGylated non-biologic drugs
EJ Park, J Choi, KC Lee, DH Na - Expert Opinion on Emerging …, 2019 - Taylor & Francis
Introduction: PEGylation is a well-established technology for improving the therapeutic value
of drugs by attaching polyethylene glycol (PEG). The first PEGylated enzyme products …
of drugs by attaching polyethylene glycol (PEG). The first PEGylated enzyme products …
PEGylation of therapeutic oligonucletides: From linear to highly branched PEG architectures
PEGylation, the attachment of poly (ethylene glycol)(PEG), has been adopted to improve the
pharmacokinetic properties of oligonucleotide therapeutics for nearly 30 years. Prior efforts …
pharmacokinetic properties of oligonucleotide therapeutics for nearly 30 years. Prior efforts …
[HTML][HTML] From synthesis to characterization of site-selective PEGylated proteins
LH Belén, CO Rangel-Yagui… - Frontiers in …, 2019 - frontiersin.org
Covalent attachment of therapeutic proteins to polyethylene glycol (PEG) is widely used for
the improvement of its pharmacokinetic and pharmacological properties, as well as the …
the improvement of its pharmacokinetic and pharmacological properties, as well as the …
Drug and protein delivery by polymer conjugation
A Grigoletto, K Maso, A Mero, A Rosato… - Journal of Drug Delivery …, 2016 - Elsevier
Drug and protein delivery techniques and methods, which, in most cases, are concurrently
investigated from the very time a new molecular entity is proposed, have become valuable …
investigated from the very time a new molecular entity is proposed, have become valuable …
Enzymatic approaches to new protein conjugates
A Grigoletto, K Maso, G Pasut - Polymer-protein conjugates, 2020 - Elsevier
Until recently, polymer–protein PEGylation has for the most part been characterized by
chemical approaches to conjugation, and, in fact, the majority of conjugates approved for …
chemical approaches to conjugation, and, in fact, the majority of conjugates approved for …
Utilization of a multiple cloning site as a versatile platform for DNA triblock copolymer synthesis
J Shin, S Li - Bioconjugate Chemistry, 2019 - ACS Publications
DNA-containing block copolymers have utility in a wide range of biomedical applications.
However, synthesis of these hybrid materials, especially ones with complex chain structures …
However, synthesis of these hybrid materials, especially ones with complex chain structures …