Chemometrics-assisted solid-state characterization of pharmaceutically relevant materials. Polymorphic substances

NL Calvo, RM Maggio, TS Kaufman - Journal of pharmaceutical and …, 2018 - Elsevier
Current regulations command to properly characterize pharmaceutically relevant solid
systems. Chemometrics comprise a range of valuable tools, suitable to process large …

Thermoanalytical techniques of nanomaterials

J Abraham, AP Mohammed, MPA Kumar… - Characterization of …, 2018 - Elsevier
Designing and fabrication of materials with good thermal characteristics is very important for
multifunctional applications of nanomaterials. Thermal analysis is a group of techniques that …

[HTML][HTML] Agglomerated novel spray-dried lactose-leucine tailored as a carrier to enhance the aerosolization performance of salbutamol sulfate from DPI formulations

C Molina, W Kaialy, Q Chen, D Commandeur… - Drug delivery and …, 2018 - Springer
Spray-drying allows to modify the physicochemical/mechanical properties of particles along
with their morphology. In the present study, L-leucine with varying concentrations (0.1, 0.5, 1 …

Understanding compression-induced amorphization of crystalline posaconazole

C Huang, G Klinzing, A Procopio, F Yang… - Molecular …, 2018 - ACS Publications
Process-induced phase transformations (PIPTs) of active pharmaceutical ingredients (APIs)
can alter APIs' physicochemical properties and impact performance of pharmaceutical drug …

Simultaneous improvement of solubility and permeability by fabricating binary glassy materials of Talinolol with Naringin: Solid state characterization, in-vivo in-situ …

A Teja, PB Musmade, AB Khade, SJ Dengale - European Journal of …, 2015 - Elsevier
The aim of the current study was to prepare binary amorphous forms of Talinolol (TLN) by
using Naringin (NRG) as a stabilizing agent. The secondary objective of this study was to …

Development, characterisation and nasal deposition of melatonin-loaded pectin/hypromellose microspheres

L Nižić, J Potaś, K Winnicka, M Szekalska, I Erak… - European journal of …, 2020 - Elsevier
In this study, we present the development of spray-dried pectin/hypromellose microspheres
as efficient melatonin carrier for targeted nasal delivery. Different pectin to hypromellose …

A solid-state chemist's view of the crystal polymorphism of organic compounds

A Gavezzotti - Journal of pharmaceutical sciences, 2007 - Elsevier
In a survey of some structural and energetic aspects of crystal polymorphism, definitions are
proposed, and a method for generating an unequivocal fingerprint of the cohesive pattern of …

Transmission low-frequency Raman spectroscopy for quantification of crystalline polymorphs in pharmaceutical tablets

M Inoue, H Hisada, T Koide, T Fukami, A Roy… - Analytical …, 2019 - ACS Publications
The purpose of this study was to quantify polymorphs of active pharmaceutical ingredients in
pharmaceutical tablets using a novel transmission low-frequency Raman spectroscopy …

Particle engineering of needle shaped crystals by wet milling and temperature cycling: Optimisation for roller compaction

D Wilson, M Bunker, D Milne, A Jawor-Baczynska… - Powder technology, 2018 - Elsevier
Purpose The purpose of this work is to demonstrate a process for the alteration of the shape
of needle shaped crystals of an active pharmaceutical ingredient (API) using a combination …

Eudragit RS 100 microparticles containing 2-hydroxypropyl-β-cyclodextrin and glutathione: Physicochemical characterization, drug release and transport studies

A Trapani, V Laquintana, N Denora, A Lopedota… - European journal of …, 2007 - Elsevier
The aim of this study was to encapsulate glutathione (GSH) alone or in combination with
hydroxypropyl-β-cyclodextrin (HP-β-CD) in Eudragit RS 100 microparticles (MPs), and to …