Use of low-frequency Raman spectroscopy and chemometrics for the quantification of crystallinity in amorphous griseofulvin tablets

PT Mah, SJ Fraser, ME Reish, T Rades… - Vibrational …, 2015 - Elsevier
Low-frequency Raman spectroscopy, which directly probes phonon lattice modes of crystal
structures, has much unexplored potential for sensitive qualitative and quantitative analysis …

Understanding the process-product-performance interplay of spray dried drug-polymer systems through complete structural and chemical characterization of single …

S Poozesh, N Setiawan, F Arce, P Sundararajan… - Powder technology, 2017 - Elsevier
A complete description of the particle formation process can only be realized with
techniques that enable the measurement of the composition and structural dependence of …

Dissolution, bioactivity behavior, and cytotoxicity of 19.58Li2O·11.10ZrO2·69.32SiO2 glass–ceramic

NM Possolli, DF da Silva, J Vieira… - … Research Part B …, 2022 - Wiley Online Library
Glass and bioactive glass–ceramic can be used in several applications. In bone growth
where good bone/biomaterial adhesion was required, bioactive coatings for implants can …

Fe3O4/Au binary nanocrystals: Facile synthesis with diverse structure evolution and highly efficient catalytic reduction with cyclability characteristics in 4-nitrophenol

Y Liu, YY Zhang, QW Kou, DD Wang, DL Han, ZY Lu… - Powder technology, 2018 - Elsevier
Fe 3 O 4/Au binary nanocrystals have been widely utilized in catalysis, biology, medicine
and other fields due to their unique magnetic and optical properties. In the present work …

Eudragit RS 100 microparticles containing 2-hydroxypropyl-β-cyclodextrin and glutathione: Physicochemical characterization, drug release and transport studies

A Trapani, V Laquintana, N Denora, A Lopedota… - European journal of …, 2007 - Elsevier
The aim of this study was to encapsulate glutathione (GSH) alone or in combination with
hydroxypropyl-β-cyclodextrin (HP-β-CD) in Eudragit RS 100 microparticles (MPs), and to …

Engineering stable spray-dried biologic powder for inhalation

N Carrigy, R Vehring - Pharmaceutical Inhalation Aerosol …, 2019 - taylorfrancis.com
This chapter reviews recent developments in the engineering of spray dried biologic powder
for inhalation, with a focus on theories and methods for developing dispersible powders with …

Nonlinear optical imaging for sensitive detection of crystals in bulk amorphous powders

US Kestur, D Wanapun, SJ Toth, LA Wegiel… - Journal of …, 2012 - Elsevier
The primary aim of this study was to evaluate the utility of second-order nonlinear imaging of
chiral crystals (SONICC) to quantify crystallinity in drug–polymer blends, including solid …

Encapsulation of cyclodextrin complexed simvastatin in chitosan nanocarriers: A novel technique for oral delivery

A Vyas, S Saraf, S Saraf - Journal of inclusion phenomena and …, 2010 - Springer
The purpose of the present work was to design and investigate the potential of novel
hydroxylpropyl-beta-cyclodextrin (HP-β-CD) and chitosan nanocarriers (NCs) for effective …

Discovery of new cocrystals beyond serendipity: lessons learned from successes and failures

SN Wong, M Fu, S Li, WTC Kwok, S Chow, KH Low… - …, 2024 - pubs.rsc.org
The past decade has witnessed remarkable progress in cocrystal research, by virtue of the
desires to address problematic properties of drugs. Notwithstanding the rapid advancements …

Critical considerations for the qualitative and quantitative determination of process‐induced disorder in crystalline solids

A Newman, G Zografi - Journal of pharmaceutical sciences, 2014 - Elsevier
Solid‐state instabilities in crystalline solids arise during processing primarily because a
certain level of structural disorder has been introduced into the crystal. Many physical …