Background Oxaliplatin-induced peripheral neuropathy (OIPN) has significant clinical impact
on the quality of life for cancer patients and is a dose limiting toxicity. Trials studying …

Paclitaxel is an essential drug in the chemotherapy of ovarian, non-small cell lung, breast,
gastric, endometrial, and pancreatic cancers. However, it frequently causes peripheral …

Oxaliplatin (OXA) is a common chemotherapy drug for colorectal, gastric, and pancreatic
cancers. The anticancer effect of OXA is often accompanied by neurotoxicity and acute and …

Оligoarginines were recently discovered (Lebedev et al., 2019 Nov) as a novel class of
nicotinic acetylcholine receptors (nAChRs) inhibitors, octaoligoarginine R8 showing a …

In recent years, 3-aminopiperidine and 3-aminoazepane have been identified as important
pharmacophores that led to the development of drugs having several billion dollar global …

Oxaliplatin is a widely used chemotherapeutic agent. Despite its many beneficial aspects in
fighting many malignancies, it shares an aversive effect of neuropathy. Many substances …

Pancreatic cancer is a more aggressive and refractory malignancy. Resistance and toxicity
limit drug efficacy. Herein, we report a lower toxic and higher effective miriplatin (MPt) …

Colorectal cancer (CRC) has been the third commonest cancer in the world. The prognosis
of patients with CRC is related to the molecular subtypes and gene mutations, which is …

Abstract Introduction/Aims Oxaliplatin is a commonly used platinum chemotherapy drug,
whereas peripheral neurotoxicity is a widely observed adverse reaction lacking a …

Almost 90% of patients develop pain immediately after oxaliplatin (OXA) treatment. Here, the
impact of aging on OXA-induced acute peripheral neuropathy and the potential of 7-chloro-4 …