Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are
an important hallmark of protein misfolding diseases and therefore have been investigated …

Conspectus Alzheimer's disease (AD) is the most common form of dementia and is
characterized by memory loss and cognitive decline. Approximately 50 million people …

The accumulation of the amyloid‐β peptides (Aβ) is central to the development of
Alzheimer's disease. The mechanism by which Aβ triggers a cascade of events that leads to …

Alzheimer's disease (AD) is the most common, age-dependent neurodegenerative disorder.
While AD has been intensively studied from different aspects, there is no effective cure for …

Amelotin is an intrinsically disordered protein (IDP) rich in Pro residues and is involved in
hydroxyapatite mineralization. It rapidly oligomerizes under physiological conditions of pH …

Recent structural studies show distinct morphologies for the fibrils of Aβ (1–42) and Aβ (1–
40), which are believed not to co-fibrillize. We describe here a novel, structurally-uniform 1: 1 …

Alzheimer's disease (AD) is an irreversible neurodegenerative disease, causing profound
social and economic implications. Early diagnosis and treatment of AD have faced great …

Protein aggregation phenomenon is closely related to the formation of amyloids which
results in many neurodegenerative diseases like Alzheimer's, Parkinson's, Huntington's, and …

Aggregation and the formation of oligomeric intermediates of amyloid-β (Aβ) at the
membrane interface of neuronal cells are implicated in the cellular toxicity and pathology of …