Critically ill patients are at high risk for development of life-threatening infection leading to
sepsis and multiple organ failure. Adequate antimicrobial therapy is pivotal for optimizing the …

Infections in critically ill patients are associated with persistently poor clinical outcomes.
These patients have severely altered and variable antibiotic pharmacokinetics and are …

Objective: To describe the prevalence and natural history of augmented renal clearance in a
cohort of recently admitted critically ill patients with normal plasma creatinine concentrations …

Traditional antibiotic dosing was not designed for today's escalating antibiotic resistance,
lack of novel antibiotics and growing complexity in patient populations. Dosing that ensures …

Augmented renal clearance (ARC) is a phenomenon in critically ill patients characterized by
increased creatinine clearance and elimination of renally eliminated medications. Patients …

Introduction The aim of this study was to compare a 7-day course of doripenem to a 10-day
course of imipenem-cilastatin for ventilator-associated pneumonia (VAP) due to Gram …

Objectives We utilized the database of the Defining Antibiotic Levels in Intensive care unit
patients (DALI) study to statistically compare the pharmacokinetic/pharmacodynamic and …

Pseudomonas aeruginosa is characterized by a notable intrinsic resistance to antibiotics,
mainly mediated by the expression of inducible chromosomic β-lactamases and the …

Introduction Improved methods to optimize drug dosing in the critically ill are urgently
needed. Traditional prescribing culture involves recognition of factors that mandate dose …

Purpose Standard dosing and intermittent bolus application (IB) are important risk factors for
pharmacokinetic (PK) target non-attainment during empirical treatment with β-lactams in …